AI Article Synopsis
- The study explores the use of colloidal gold nanoparticles (AuNPs) as a blood-pool agent for enhancing x-ray computed tomography (CT) imaging.
- The researchers modified gold nanocrystals with polyethylene glycol (PEG) and tested their safety in mice, finding no toxicity and confirming the nanoparticles' imaging efficacy.
- Results demonstrated that AuNPs could effectively visualize tumor vasculature within a stable imaging timeframe post-injection, suggesting their potential for advanced medical imaging applications.*
Article Abstract
Objectives: To present the pharmacokinetics and computed tomographic imaging efficacy of colloidal gold nanoparticles (AuNPs) as a blood-pool agent for x-ray computed tomography (CT).
Methods And Materials: To prepare the colloidal AuNPs, gold nanocrystals were modified using sulfhydrated polyethylene glycol (PEG). Cytotoxicity and histopathologic tests were carried out for toxicity evaluation. Six adult Balb/c mice underwent microcomputed tomography scans after injection of colloidal AuNPs (2.5 micromol Au/g body weight). Four mice with HT-1080 tumors were imaged for visualization of the tumor vasculature.
Results: The PEG coated colloidal AuNPs appeared as spherical nanoparticles with 38-nm diameters. The AuNPs-PEG showed a biocompatibility without toxicity in the mice. We identified a stable imaging window for visualizing the vasculature system, immediately to 24 hours after injection. Microcomputed tomography imaging using AuNPs-PEG clearly visualized the tumor vascular structures.
Conclusion: Colloidal AuNPs show potential as a blood-pool agent for x-ray CT imaging.
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| http://dx.doi.org/10.1097/RLI.0b013e31811ecdcd | DOI Listing |
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