Analysed herein are the outcomes of a comprehensive (clinical, ultrasonographic and magnetic-resonance) examination of 322 patients with symptomatology of ischemic disorders of cerebral circulation, undergoing treatment at a neurological hospital. Of these, a total of 194 (60 %) patients were found to have various types of pathology of the internal carotid arteries (ICA). Pathological kinking of the internal carotid arteries was revealed in 56 (17.4%) subjects. Based on the findings of the clinical and instrumental examination we managed to specify the definition of pathological kinking. Also determined were peculiarities of the circle of Willis, promoting manifestations of cerebral circulation insufficiency in patients presenting with pathological kinking. Studied were the long-term outcomes (up to 4 years) of surgical treatment of 56 patients with pathological kinking of the ICA. Good immediate outcomes of surgical operations were observed, to be followed by considerably decreased neurological symptomatology in the remote postoperative period.
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Background: Hindfoot endoscopy is an effective treatment for posterior ankle impingement syndrome (PAIS) and flexor hallucis longus (FHL) tendon disorders. However, FHL tendoscopy, especially from the posteromedial portal, carries a risk of tibial nerve damage. A needle-arthroscopic system with a 1.
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December 2024
Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Developmental Disability Center, 713-8 Kamiya, Kasugai 480-0392, Japan.
encodes a small GTPase of the Rho family that plays a critical role in actin cytoskeleton remodeling and intracellular signaling regulation. Pathogenic variants in , all of which reported thus far affect conserved residues within its functional domains, have been linked to neurodevelopmental disorders characterized by diverse phenotypic features, including structural brain anomalies and facial dysmorphism (NEDBAF). Recently, a novel de novo variant (NM_005052.
View Article and Find Full Text PDFDevelopment
November 2024
Azrieli Research Center of CHU Sainte Justine, University of Montreal, Montreal H3T 1C5, QC, Canada.
Congenital scoliosis (CS) is a type of vertebral malformation for which the etiology remains elusive. The notochord is pivotal for vertebrae development, but its role in CS is still understudied. Here, we generated a zebrafish knockout of ptk7a, a planar cell polarity (PCP) gene that is essential for convergence and extension (C&E) of the notochord, and detected congenital scoliosis-like vertebral malformations (CVMs).
View Article and Find Full Text PDFCancer Discov
October 2024
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan.
J Glaucoma
August 2024
Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.
Prcis: A large disk, a large parapapillary delta zone and a long axial length may be used as screening criteria to detect glaucomatous optic neuropathy in highly myopic eyes.
Purpose: To describe aspects for screening of glaucomatous optic neuropathy in dependence of refractive error, under special consideration of high myopia.
Methods/results: Studies on the anatomy of the myopic optic nerve head and results of investigations on the relationship between glaucomatous optic neuropathy and axial myopia were included.
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