AI Article Synopsis
- Essential hypertension is a complex and prevalent condition, with extensive research aiming to identify the genetic factors involved.
- Recent genome-wide studies have struggled to pinpoint definitive hypertension susceptibility genes, leading to a new high-density association study involving multiple tiers of SNP genotyping.
- The study revealed nine significant SNPs linked to hypertension across different genomic loci, with the top candidate being rs3755351 in the ADD2 gene, highlighting the need for further research to confirm these findings.
Article Abstract
Essential hypertension is one of the most common, complex diseases, of which considerable efforts have been made to unravel the pathophysiological mechanisms. Over the last decade, multiple genome-wide linkage analyses have been conducted using 300-900 microsatellite markers but no single study has yielded definitive evidence for 'principal' hypertension susceptibility gene(s). Here, we performed a three-tiered, high-density association study of hypertension, which has been recently made possible. For tier 1, we genotyped 80 795 SNPs distributed throughout the genome in 188 male hypertensive subjects and two general population control groups (752 subjects per group). For tier 2 (752 hypertensive and 752 normotensive subjects), we genotyped a panel of 2676 SNPs selected (odds ratio >or= 1.4 and P
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http://dx.doi.org/10.1093/hmg/ddm335 DOI Listing Publication Analysis
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