Accuracy of local conduction velocity determination from non-fractionated cardiac activation signals.

Local velocity and direction of cardiac excitation spread can be estimated from four extra-cellular electric potential waveforms recorded simultaneously by closely-spaced electrodes. In this work, three methods for the determination of these parameters in case of non-fractionated electrograms were compared. Waveforms recorded during in-vitro experiments were analyzed in terms of their noise components. Noise according to the experimental environment was generated and added to noise-free waveforms obtained from computer simulations. For each of the three investigated methods the accuracy of the determined parameters velocity and direction was evaluated for three different noise levels and three types of propagation.