Five patients with nephropathic cystinosis were evaluated to assess the ability of topical cysteamine to clear corneal cystine crystals. All patients were randomised to receive topical cysteamine 0.2% six times a day in one eye with normal saline in the other eye as a control. All five patients showed some improvement in visual symptoms (photophobia, blepharospasm and visual acuity) together with an improvement in corneal crystal density. Three of these also had an improvement in Snellen visual acuity and contrast sensitivity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/eye.1991.139 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Case Series With Cysteamine-Isobionicamide Complex: Clues for Skin-Rejuvenating Activity.
J Cosmet Dermatol
January 2025
Scientis SA, Geneva, Switzerland.
Background: Skin aging is inevitable. Wrinkles, skin texture abnormalities, senile hyperpigmentation, loss of skin tone, dryness, atrophy, and telangiectasias represent some of the hallmarks of aged skin. Skin rejuvenation can be addressed by topical therapies, such as topical retinoids and antioxidants or physical modalities with energy-based devices, all providing acceptable outcomes.
View Article and Find Full Text PDFClinical Efficacy of Cysteamine Application for Melasma: A Meta-Analysis.
J Clin Med
December 2024
20skin Four Seasons Clinic, Taichung 408, Taiwan.
Melasma is a challenging, acquired hyperpigmentary disorder. The gold standard treatment is Kligman's formulation, which contains hydroquinone, tretinoin, and dexamethasone, but its long-term use is limited by the risk of exogenous ochronosis. Cysteamine, a tyrosinase inhibitor, reduces melanocyte activity and melanin production, showing strong depigmenting effects in patients resistant to Kligman's formulation.
View Article and Find Full Text PDFEfficacy and safety of cysteamine 5% cream for the management of melasma: a systematic review and meta-analysis of randomized controlled trials.
Arch Dermatol Res
December 2024
Department of Dermatology and Venereology, Faculty of Medicine, Sam Ratulangi University/R. D. Kandou Hospital, Manado, North Sulawesi, Indonesia.
Currently, hydroquinone serves as topical treatment of choice for melasma. However, its long-term use was associated with melanocyte toxicity. Cysteamine is an aminothiol that possesses antioxidant and depigmenting properties, therefore potentially suitable for treating melasma.
View Article and Find Full Text PDFEfficacy and Safety of Combination Therapy of Microneedling Radiofrequency, In-Office and Home-Based Topical Cysteamine in Refractory Melasma: A Split Face, Vehicle-Control, Randomized Control Trial.
J Cosmet Dermatol
November 2024
School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Background: Refractory melasma remains a challenge in dermatology, necessitating the exploration of innovative treatments.
Aims: This study aims to evaluate the efficacy and safety of combining radiofrequency microneedling (RFM) with Cysteamine cream, applied both in-office and as a part of a home-care regimen, to treat refractory melasma.
Patients/methods: A vehicle-controlled, split-face trial was conducted on 30 Fitzpatrick skin types III and IV participants.
Adherence to Cysteamine Therapy Among Patients Diagnosed with Cystinosis in Saudi Arabia: A Prospective Cohort Study.
Pharmacy (Basel)
August 2024
Department of Kidney and Pancreas Transplant, King Faisal Specialist Hospital and Research Centre, Riyadh P.O. Box 3354, Saudi Arabia.
Cystinosis is a rare autosomal recessive disorder in which cystine crystals accumulate within the cellular lysosomes, causing damage to multiple organs. Due to challenges with the stringent cysteamine treatment regimen and side effects, adherence is often sub-optimal. This study aimed to assess the level of adherence to cysteamine therapy among cystinosis patients in Saudi Arabia and its impact on their quality of life.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!