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Daily torpor affects the molecular machinery of the circadian clock in Djungarian hamsters (Phodopus sungorus). | LitMetric

Daily torpor affects the molecular machinery of the circadian clock in Djungarian hamsters (Phodopus sungorus).

Eur J Neurosci

Département de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Intégratives, UMR-7168/LC2, CNRS-Université Louis Pasteur, Strasbourg, France.

Published: November 2007

AI Article Synopsis

  • - The study examines how daily torpor in Djungarian hamsters is tied to their circadian clock in the hypothalamus, noting that during torpor their body temperature drops to around 15 degrees Celsius.
  • - Researchers analyzed the expression of specific clock genes and proteins in the hamsters' suprachiasmatic nuclei (SCN) and pineal gland during both torpor and normal temperature conditions.
  • - Findings indicate that while some rhythmic gene expressions persist during torpor, the cold environment may alter the genes' phases and amplitudes due to reduced protein synthesis, suggesting that temperature influences the circadian system.

Article Abstract

Daily torpor in the Djungarian hamster (Phodopus sungorus) is a precisely timed event gated by the circadian clock situated in the suprachiasmatic nuclei (SCN) of the hypothalamus. Timing-controlled hypothermia during which body temperature (Tb) decreases to approximately 15 degrees C implies temperature compensation of the circadian system. Nevertheless, it remains controversial how the molecular clockwork functions at those low Tb values and whether the torpor bout affects the circadian system. In this study, we investigated rhythmic clock and clock-related gene as well as protein expression in the SCN and pineal gland of torpid and normothermic Djungarian hamsters over a 48 h cycle. We clearly demonstrate rhythmic gene expression of Per1, Bmal1 and Avp in the SCN as well as Aa-nat in the pineal gland on a day of torpor. Alterations in the phase and amplitude of these rhythms, however, may be due to decreased protein synthesis during hypothermia. This decreased protein feedback resulting from the hypothermia might also be responsible for changes in gene expression observed 1 day after a torpor bout. We conclude that temperature has at least a modulatory effect on the circadian system.

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Source
http://dx.doi.org/10.1111/j.1460-9568.2007.05927.xDOI Listing

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