Ten male firefighters were tested on a treadmill to determine their heart rate (HR) x oxygen consumption (VO2) relationship. These men then performed a simulated fire suppression protocol during which HR and VO2 were measured simultaneously by a portable physiological monitoring system. Average VO2 in the simulated setting was 31.0 +/- 7.0 ml.kg-1.min-1 at a HR of 176 +/- 9 bpm. This VO2 was significantly (p less than or equal to 0.05) less than the VO2 that would have been predicted by treadmill testing (38.9 +/- 5.0 ml.kg-1.min-1) at a corresponding HR. Fifty-nine per cent of this variability could be accounted for by regression analysis. Firefighters worked on average at 73 +/- 10% VO2 max with a range of 54% to 88%. There was a significant (-0.82; p less than or equal to 0.05) inverse relationship between performance time of the fire suppression protocol and the relative intensity of VO2 max at which the firefighters worked. These findings indicate that the prediction of energy expenditure from HR is not straightforward in fire suppression settings. Furthermore, the relative intensity of work firefighters self-select is variable and should be considered as an additional physiological determinant of work behaviour.
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J Environ Manage
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School of Environmental Sciences, University of East Anglia, Norwich Research Park, Norwich, Norfolk, NR4 7TJ, UK; Instituto Juruá, Manaus, Brazil.
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Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via Eudossiana 18, 00184 Rome, Italy.
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China Academy of Safety Science and Technology, Beijing 100012, China. Electronic address:
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Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, Uppsala 75651, Sweden.
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View Article and Find Full Text PDFAdv Sci (Weinh)
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Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol-functionalized BP (BP-PEG) nanosheets in breast cancer models. Using immunocompetent mouse models-including 4T1 orthotopic BALB/c mice and MMTV-PyMT transgenic mice, it is found that BP-PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells.
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