AI Article Synopsis
- Radiation therapy, while commonly used for treating cancers, can lead to rare secondary cancers like angiosarcomas, as seen in a 67-year-old man ten years after treatment for a giant cell tumor.
- The patient presented with swelling and X-rays showed damage to the humerus; he had surgery to remove the affected bone and received a prosthetic implant.
- After a recurrence of the angiosarcoma a year later, he underwent further surgery and chemotherapy, and is now free of cancer after six months of monitoring.
Article Abstract
Radiation therapy is extensively used for treatment of malignancies, but angiosarcomas occurring in an irradiated area are uncommon. We report a rare case of high-grade epithelioid angiosarcoma of upper end of right humerus in a 67-year-old male occurring ten years following irradiation for giant cell tumor of the same anatomical site. The patient presented with progressive painful swelling over right shoulder and his X-ray showed erosion of medial cortex with lytic areas at upper end of humerus. He underwent excision of affected part of humerus followed by cemented hemiarthroplasty and bone grafting. After initial histopathological diagnostic dilemma the final report was given as post-radiation angiosarcoma. Disease recurred at the end of one-year follow-up period where upon he underwent wide resection with prosthesis replacement. He received four cycles of combination chemotherapy with doxorubicin and ifosfamide and currently is free of recurrence after six months follow-up.
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| http://dx.doi.org/10.4103/0973-1482.34687 | DOI Listing |
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