Background: Dupuytren's disease (DD) is a hand disease inherited as an autosomal dominant trait with variable penetrance, especially among populations of northern European ancestry. The etiology and pathophysiology of DD are not clear. The purpose of this study was to examine the gene expression profiles of palmar fascia of DD and healthy patients using microarray analysis to highlight the genes that might contribute to the pathogenesis of DD.
Materials And Methods: Dupuytren contracture samples were taken from excised mature cords of DD patients during aponeurectomies. Control samples were collected from healthy hand trauma patients. Microarray analysis was performed with the Affymetrix HGU133A genome array (Affymetrix, Santa Clara, CA). Expression changes of selected proteins were confirmed at the protein level with Western and dot blotting or by immunohistochemistry.
Results: At least an 8-fold change in gene expression was found with 127 genes, including a 90-fold down-regulation of myoglobin and a 14-fold up-regulation of tyrosine kinase-like orphan receptor 2 (= ROR2) from absent to present during the disease. The changes in myoglobin and ROR2 expression were confirmed at the protein level.
Conclusions: In this study, we showed for the first time the connection of ROR2 in Dupuytren's disease. ROR2 and myoglobin may play an important role in the pathophysiology of this disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jss.2007.06.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The importance of multiple Z- plasty- assisted physical therapy in the treatment of Dupuytren's contracture.
J Orthop Surg Res
January 2025
Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background: The palmar aponeurosis is extremely adherent to the skin above it. Many of the pre-tendinous coarse fibers enter the dermis at an angle, not just in the palmar creases but also throughout the palm. It's difficult to distinguish whether Dupuytren's illness starts in the skin's dermis or the palmar aponeurosis since the skin adheres so closely to the palmar fascia.
View Article and Find Full Text PDFAdjuvant steroid to percutaneous needle fasciotomy for Dupuytren's contracture. An RCT study protocol.
Dan Med J
November 2024
Department of Clinical Medicine, Aarhus University.
Introduction: Percutaneous needle fasciotomy (PNF) is a non-invasive treatment option for finger flexion contractures caused by Dupuytren's disease. Variations in PNF techniques include the use of corticosteroid injection. In the presented randomised controlled trial, we compare the efficacy of PNF +/- corticosteroid injection in terms of reducing the recurrence rate.
View Article and Find Full Text PDFDupuytren's Contracture: A Review of the Literature.
Cureus
December 2024
Department of Orthopedics, Liverpool University Hospitals National Health Service (NHS) Foundation Trust, Liverpool, GBR.
Dupuytren's contracture is a chronic condition that affects the palmar fascia, leading to progressive flexion of the fingers, particularly the ring and little fingers. This article provides an in-depth review of the current understanding of the condition and its management. Commonly seen in older men of Northern European descent, Dupuytren's can significantly impair hand function as contractures develop.
View Article and Find Full Text PDFRecurrent Refractory Non-Dupuytren Contracture in Females After Limited Fasciectomy.
Cureus
December 2024
Department of Orthopaedics, Niigata Hand Surgery Foundation, Seiro-machi, JPN.
Article Synopsis
- Non-Dupuytren's contracture, often resulting from trauma or surgery, usually doesn't need surgery; however, in this case, an 81-year-old woman had a series of surgeries for finger issues, leading to ongoing complications.
- During her surgeries, procedures like limited fasciectomy, flexor tenolysis, and joint mobilization were performed, but the flexion contracture persisted after initial attempts.
- Ultimately, despite multiple interventions including excision of the cord and attempts to improve motion, the flexion contracture recurred, highlighting the need to anticipate potential recurrence in surgical planning for non-Dupuytren's contracture.
Risk and Mortality of Cardiovascular Diseases in Patients with Dupuytren's Disease: A Nationwide Population-Based Cohort Study.
Plast Reconstr Surg
December 2024
Department of Plastic and Reconstructive Surgery.
Background: Dupuytren's disease (DD) is a type of fibroproliferative disease that involves the palmar aspect of the hand. Although many benign fibroproliferative diseases have been shown to increase the risk of cardiovascular disease, the relationship between DD and myocardial infarction (MI) or stroke has not been fully elucidated.
Methods: A total of 35,909 patients with DD and a control cohort with 1,077,270 age- and sex-matched participants from the Korean National Health Insurance database were included.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!