Influence of genetic polymorphisms in the apolipoprotein (APOE) and the butyrylcholinesterase (BCHE) gene on stress markers in older adults: a 3-year study.
Neurobiol Aging
Douglas Hospital Research Centre, Verdun, Quebec H4H 1R3, Canada.
Published: June 2009
The present study examined the influence of genetic polymorphisms in the apolipoprotein (APOE) and the butyrylcholinesterase (BCHE) gene on GC secretion, cognition and personality in 66 healthy older adults. These particular variables were chosen given that they have been shown to be associated with human stress (i.e.stress markers). Measures included basal serum GC levels and cognitive scores on declarative memory obtained annually over 3 years. Also, self-esteem, neuroticism and depression were evaluated. Results showed that participants with the APOE E4-BCHE K variant (E4-K group) present increased basal levels of GCs and poorer cognitive performance when compared to non-carriers of these variants. In addition, the E4-K group reported lower self-esteem and higher levels of depression. These findings may indicate a genotype effect on markers of stress and cognitive integrity years before symptoms of dementia are apparent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neurobiolaging.2007.09.008 | DOI Listing |
Similar Publications
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome.
Elife
March 2025
Department of Cell Biology, Duke University, Durham, Durham, United States.
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome-rich enterocytes (LREs). The gut microbiome has been shown to enhance absorption of nutrients, such as lipids, by intestinal epithelial cells. However, whether protein absorption is also affected by the gut microbiome is poorly understood.
View Article and Find Full Text PDFInheritance of Class III Soft Tissue Facial Features from Parents to Offsprings Using Photogrammetric Analysis Technique.
J Contemp Dent Pract
December 2024
Department of Orthodontics, RRDC&H, Bengaluru, Karnataka, India.
Aim: The present study was undertaken to analyze the facial features in class III patients by measuring the facial frontal (linear) parameters and profile (angular) parameters and correlate them with parents to determine the inheritance of facial features.
Materials And Methods: The sample consisted of 40 class III patients aged between 9 and 18 years based on skeletal ANB angle (less than 0 degrees) and Angle's class III classification. Frontal and profile photographs of the subjects and parents were taken in a standardized position according to ABO guidelines.
Optimized Protocol For DNA Extraction from Human Whole Blood.
Cell Physiol Biochem
January 2025
Pomeranian University in Słupsk, Institute of Biology, Arciszewski St. 22 B, PL 76-200 Słupsk, Poland.
Background/aims: DNA isolation is the initial process in genetic research. The product is used in many PCR reactions (PCR-RFLP, Real-Time PCR, multiplex PCR). That is why it is important to optimize DNA isolation protocol to obtain a good quality of DNA.
View Article and Find Full Text PDFVery Late-Onset Neurodegeneration with Brain Iron Accumulation Associated with Mild Chorea: A Clinicopathological Case.
Mov Disord Clin Pract
March 2025
Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Background: Neurodegeneration with Brain Iron Accumulation (NBIA) rarely manifests after the age of 50 years. The phenotype in these cases is most often parkinsonism.
Objectives: To present the case with the oldest age of NBIA onset reported so far.
Broiler litter moisture and trace metals contribute to the persistence of strains that harbor large plasmids carrying siderophores.
Appl Environ Microbiol
March 2025
U.S. National Poultry Research Center, USDA-ARS, Athens, Georgia, USA.
Broiler litter sampling has proven to be an effective method for determining the status of a broiler chicken flock and understanding the ecology of prior to harvest. In this study, we investigated the ecology of within the litter ( = 224) from two commercial broiler houses in the United States. We employed culture enrichment methods and quantitative polymerase chain reaction to determine the prevalence and load of and utilized antimicrobial susceptibility testing and whole-genome sequencing (WGS) to characterize select isolates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.