AI Article Synopsis
- Physiological blood coagulation is a crucial process that occurs after a blood vessel injury, involving a series of enzymatic reactions leading to clot formation.
- The study uses dynamic light scattering (DLS) imaging to track red cell movement as a measure of blood coagulation, particularly after applying laser injury on mechanically occluded blood vessels.
- The method is noninvasive and user-friendly, making it a valuable tool for studying blood clotting dynamics within the circulatory system.
Article Abstract
Physiological blood coagulation/clotting is an essential biological process that is initiated by vessel injury and includes a cascade of enzymatic reactions finalized by fibrin polymerization and clot formation. We utilize dynamic light scattering (DLS) imaging to monitor in vivo red cell mobility as an indicator of blood coagulation. In the course of the experiments, blood flow is arrested using mechanical occlusion, and then laser injury is applied. We demonstrate that the combination of laser injury with DLS imaging on occluded blood vessels (i.e., under static conditions) is suitable to detect even subtle changes of plasma viscosity in the circulatory system, which reflects the process of clot development. This approach is noninvasive and has a relatively simple and easy-to-use technical design. Thus, the proposed methodology provides a promising tool for investigating blood clotting within the vasculature.
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| http://dx.doi.org/10.1117/1.2778695 | DOI Listing |
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