AI Article Synopsis
- Both high and low levels of MeCP2 are linked to neurodevelopmental issues.
- MicroRNA 132 (miR132) regulates the translation of MeCP2, affecting its levels in neurons.
- Disruption of this regulation affects both MeCP2 and BDNF levels, hinting at a feedback loop for maintaining MeCP2 expression stability.
Article Abstract
Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.
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| http://dx.doi.org/10.1038/nn2010 | DOI Listing |
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