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Predicting phage-host interaction via hyperbolic Poincaré graph embedding and large-scale protein language technique.
iScience
January 2025
Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, the College of Life Sciences, Northwest University, Xi'an 710069, China.
Bacteriophages (phages) are increasingly viewed as a promising alternative for the treatment of antibiotic-resistant bacterial infections. However, the diversity of host ranges complicates the identification of target phages. Existing computational tools often fail to accurately identify phages across different bacterial species.
View Article and Find Full Text PDFMechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells.
iScience
January 2025
Department of Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China.
Studies have shown that circRNAs play an important regulatory role in trophoblast function and embryonic development. Based on sequencing and functional experiments, we found that hsa_circ_0069443 can regulate the function of trophoblast cells, and its presence is found in the exosomes secreted by trophoblast cells. It is known that exosomes mediate the interaction between the uterus and embryo, which is crucial for successful pregnancy.
View Article and Find Full Text PDFCan non-human primates extract the linear trend from a noisy scatterplot?
iScience
January 2025
Cognitive Neuroimaging Unit, CEA, INSERM, Université Paris-Saclay, NeuroSpin Center, 91191 Gif/Yvette, France.
Recent studies showed that humans, regardless of age, education, and culture, can extract the linear trend of a noisy scatterplot. Although this capacity looks sophisticated, it may simply reflect the extraction of the principal trend of the graph, as if the cloud of dots was processed as an oriented object. To test this idea, we trained Guinea baboons to associate arbitrary shapes with the increasing or decreasing trends of noiseless and noisy scatterplots, while varying the number of points, the noise level, and the regression slope.
View Article and Find Full Text PDFEuropean agrifood and forestry education for a sustainable future - Gap analysis from an informatics approach.
Open Res Eur
October 2024
Department of Process and Life Science Engineering, Division of Food and Pharma, LTH, Faculty of Engineering, Lund University, Lund, Skåne County, SE-221 00, Sweden.
Background: The NextFood Project ( www.nextfood-project.eu) started work in 2018 to identify 'Categories of Skills' that students should be equipped with to address the upcoming global challenges within agrifood and forestry disciplines, and involved concepts such as sustainability, technological adaptation and networking.
View Article and Find Full Text PDFFacilitating children's communication in problem-solving activities with a coding toy: teachers' semiotic mediation in early childhood education and care.
Front Psychol
January 2025
Department of Early Childhood Education, University of Stavanger, Stavanger, Norway.
This study investigates the role of teacher mediation in facilitating children's communication during problem-solving, play-based coding activities with Kubo, a screen-free coding toy, in Early Childhood Education and Care (ECEC) settings. Following an initial observation involving nine kindergarten teachers and 36 children, a workshop was held to identify elements that teachers considered relevant for facilitating children's use of verbal and non-verbal communication. Key mediation elements, such as multimodal communication, planning, time, humor, and reflective questioning, were identified during the workshop and applied in a subsequent observation with the same participants.
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