Sanhuang tablets is one of common traditional Chinese patent preparation, it has effects of clear fever, detoxifcation, dispel inflammation, purgation. It was contained in the ministerial standards of Ministry of Health in 1997, and was contained in Chinese pharmacopoeia version 1 of 2000 and 2005. Its improvement of dosage form, preparation technique, quality analysis, pharmacology and clinical usage were reviewed in this paper.
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[ tablet inhibits endoplasmic reticulum stress and autophagy in diabetic mouse islet cells].
Nan Fang Yi Ke Da Xue Xue Bao
September 2022
Health Management Center, Third Affiliated Hospital, Southern Medical University, Guangzhou 510000, China.
Objective: To investigate effects of tablet (JTSHT) for regulating blood glucose and alleviating islet cell damage in db/db mice and its protective effects against endoplasmic reticulum stress (ERS) and autophagy induced by glycolipid toxicity.
Methods: Forty db/db mice were randomized into 4 groups for daily intragastric administration of saline, JTSHT of 2.64 and 1.
Sanhuang Jiangtang tablet protects type 2 diabetes osteoporosis via AKT-GSK3β-NFATc1 signaling pathway by integrating bioinformatics analysis and experimental validation.
J Ethnopharmacol
June 2021
Department of Orthopaedics, First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Baiyun Area, Guangzho, 510405, PR China. Electronic address:
Ethnopharmacological Relevance: Sanhuang Jiangtang tablet (SHJTT), has been widely used to treat type 2 diabetes mellitus (T2DM). However, the potential and mechanism of SHJTT in treating type 2 diabetes osteoporosis (T2DOP) has not been reported.
Aim Of The Study: The aim of this work was to investigate the role and the underlying molecular mechanism of SHJTT in managing type 2 diabetes osteoporosis.
Application of pseudotargeted method combined with multivariate statistical analysis for the quality assessment of traditional Chinese medicine preparation, Sanhuang Tablet as a case.
Anal Bioanal Chem
September 2020
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China.
The quality control of traditional Chinese herbal medicine (TCHM) is considered to be one of the constraints for its modernization and globalization, especially for traditional Chinese medicine preparation (TCMP). The active compounds at high concentration in TCMP are usually selected as markers for qualification and quantification analyses, but we thought these compounds are insufficient to represent the quality of TCMP. For the in-depth investigation, a pseudotargeted analysis method using ultra-high-performance liquid chromatography-quadrupole-orbitrap mass spectrometry operated in the parallel reaction monitoring mode with time-staggered ion list (tsPRM) was proposed to recognize the chemical composition of TCMP.
View Article and Find Full Text PDF[UPLC-Q-TOF/MS for rapid analysis of chemical constituents in Sanhuang tablets].
Zhongguo Zhong Yao Za Zhi
May 2017
Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China.
The qualitative analysis method of ultra performance liquid chromatography tandem quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS/MS) was established for the chemical constituents in Sanhuang tablets. Waters ACQUITY BEH C₁₈ (2.1 mm×100 mm, 1.
View Article and Find Full Text PDFHolistic evaluation of San-Huang Tablets using a combination of multi-wavelength quantitative fingerprinting and radical-scavenging assays.
Chin J Nat Med
April 2017
College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
The present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets (SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography (HPLC) with a diode array detector (DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method (SLQFM) coupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively. Additionally, the component-activity relationship between chromatographic fingerprints and total radical-scavenging capacity in vitro (as assessed using the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) assay) was investigated by partial least squares regression (PLSR) analysis to predict the antioxidant capacity of new samples from the chromatographic fingerprints and identify the main active constituents that can be used as the target markers for the quality control of SHT.
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