Llinos Haf Spencer reports on the use of the cluster analysis statistical technique in nursing research and uses data from the Welsh Language Awareness in Healthcare Provision in Wales survey as an exemplar She concludes that cluster analysis is a valuable tool to tease out patterns in data that are not initially evident in bivariate analyses and thus should be considered as a viable option for nursing research.
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http://dx.doi.org/10.7748/nr2007.10.15.1.37.c6054 | DOI Listing |
SLAS Technol
March 2025
Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital, Southwest Medical University, Luzhou 646000, Sichuan, China; Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Luzhou 646000, Sichuan, China; Institute of Stomatology, Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address:
Background: Almost 90% of head and neck malignancies are malignant squamous cell cancers, making it the sixth most common malignancy in the developing countries, with an overall five-year overall survival rate about 40%-50%. Early diagnosis and treatment can bring a better prognosis. Fibroblast growth factor (FGF) is an important polypeptide in vivo.
View Article and Find Full Text PDFJ Affect Disord
March 2025
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address:
Background: Military sexual trauma (MST) has been linked to a range of negative mental health outcomes-posttraumatic stress disorder (PTSD) most notably. This article uses a causal inference framework based on the Rubin Causal Model to investigate the relationship between MST exposure and PTSD symptom severity.
Methods: Using data from 2488 treatment-seeking veterans and service members, we reconstructed a hypothetical randomized control trial consisting of a group with MST exposure and one without.
Cancer Cell
March 2025
Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:
PDGFRA is crucial to tumorigenesis and frequently genomically altered in high-grade glioma (HGG). In a comprehensive dataset of pediatric HGG (n = 261), we detect PDGFRA mutations and/or amplifications in 15% of cases, suggesting PDGFRA as a therapeutic target. We reveal that the PDGFRA/KIT inhibitor avapritinib shows (1) selectivity for PDGFRA inhibition, (2) distinct patterns of subcellular effects, (3) in vitro and in vivo activity in patient-derived HGG models, and (4) effective blood-brain barrier penetration in mice and humans.
View Article and Find Full Text PDFComput Biol Chem
March 2025
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Institute of Urology, Capital Medical University, Beijing, China. Electronic address:
Background: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflammatory response during the IRI process. The objective of this study is to conduct an analysis of the developmental and differentiation characteristics of macrophages in IRI, identify distinct molecules subtypes of IRI, and establish robust predictive strategies for DGF and graft survival.
View Article and Find Full Text PDFPoult Sci
March 2025
College of Animal Science, South China Agricultural University, Guangzhou 510642, PR China.
Duck Associated Chapparvovirus (DaChPV) is a newly discovered virus within the Chaphamparvovirus genus, and first identified from Canadian wild ducks in 2021. In this study, DaChPV DNA was detected in 14 out of 137 tissues samples collected from diarrhea ducks across various provinces in China. Subsequently, eight complete genome sequences were amplified using overlapping primers and sequenced.
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