Objective: To study morphofunctional alterations induced by brief pressure increases in human saphenous veins utilized in coronary artery bypass grafting.
Method: Saphenous veins of 20 patients undergoing coronary artery bypass grafting, were distributed into four experimental groups, control, 100 mmHg, 200 mmHg and 300 mmHg, and submitted to pressure distention over 15 seconds using Krebs solution. The evaluation included CD34 immunohistochemistry and an In vitro vascular reactivity study in organ chambers.
Results: The main experimental findings were 1) From pressures of 200 mmHg there was a tendency to reduce the CD34 expression which became statistically significant at 300 mmHg; 2) There was no impairment of the contraction and relaxation as evidenced by in vitro vascular reactivity tests.
Conclusion: Although vascular reactivity impairment was not demonstrated in vitro, the CD34 expression, measured by immunohistochemistry, shows there is endothelium dysfunction at pressures of 300 mmHg.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s0102-76382007000200004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute kidney injury and tacrolimus toxicity in a kidney transplant recipient treated with nirmaltrevir/ritonavir: a case report.
J Med Case Rep
December 2024
Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Australia.
Background: Kidney transplant recipients with severe acute respiratory syndrome-coronavirus-2 infection have an increased risk of severe disease and mortality. Nirmaltrevir/ritonavir (Paxlovid) is an effective oral disease-modifying therapy that has been shown to reduce risk of progression to severe disease in high-risk, nonhospitalized adults. However, owing to the potential for serious drug-drug interactions owing to ritonavir-induced inhibition of the CYP3A enzyme, this drug is not suitable option for transplant recipients with mild-moderate severe acute respiratory syndrome-coronavirus-2 infection.
View Article and Find Full Text PDFImproving diabetes self-management and control through individualized patient counseling: A quasi-experimental study.
J Educ Health Promot
October 2024
Department of Community Medicine, Shri M. P. Shah Government Medical College, Jamnagar, Gujarat, India.
Background: Diabetes is one of the most common chronic diseases, affecting a large proportion of the global population. This study aims to evaluate the effects of individualized patient counseling on diabetes self-management.
Materials And Methods: This quasi-experimental study utilized a non-randomized two-arm pre-post design.
Background: After six cycles of using the BpTRU (BT) BPM-300 blood pressure (BP) monitor, the Canadian Health Measures Survey (CHMS) introduced the OMRON (OM) IntelliSense HEM-907XL BP monitor in Cycle 7. This study assesses differences between BP values measured by both devices in children and youth aged 6 to 17 years and whether equations could be developed to compare BP measurements taken using the two devices.
Data And Methods: In Cycle 6 (2018 to 2019) of the CHMS, BP was measured using BT and OM devices.
Left of sternum compressions are associated with higher systolic blood pressure than lower half of sternum compressions in cardiac arrest.
Resuscitation
December 2024
Northwell, New Hyde Park, New York, United States; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States.
Introduction: Limited evidence supports guidelines to perform chest compressions at the lower half of the sternum. Imaging studies suggest this location may obstruct blood flow. Our primary aim was to compare the highest arterial line systolic blood pressure (SBP) during lower-half-of-sternum chest compressions (CC) versus those left-of-sternum, where the left ventricle is more likely located.
View Article and Find Full Text PDFPhysiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF.
BMC Pulm Med
December 2024
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, 210009, China.
Background: Prone positioning (PP) improves oxygenation in awake patients with acute hypoxemic respiratory failure (AHRF). However, the underlying mechanisms remain unclear in patients with diverse lung morphology. We aimed to determine the short-term effects of awake prone positioning (APP) in AHRF patients with focal and non-focal lung morphology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!