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Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways.
Front Immunol
January 2025
Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Introduction: The gut microbiota plays a pivotal role in influencing host health, through the production of metabolites and other key signalling molecules. While the impact of specific metabolites or taxa on host cells is well-documented, the broader impact of a disrupted microbiota on immune homeostasis is less understood, which is particularly important in the context of the increasing overuse of antibiotics.
Methods: Female C57BL/6 mice were gavaged twice daily for four weeks with Vancomycin, Polymyxin B, or PBS (control).
Recent Advancements in Robotic-assisted Plastic Surgery Procedures: A Systematic Review.
Plast Reconstr Surg Glob Open
January 2025
Department of Plastic and Reconstructive Surgery, Royal Free NHS Foundation Trust, London, United Kingdom.
Background: There has been a delayed, yet steady uptake of robotic-assisted surgery over the past decade within the field of plastic surgery. In an era of rapidly evolving scientific and technological development, there is a need for an update on the current literature for robotic-assisted plastic surgery procedures.
Methods: Searches were conducted across major databases, including MEDLINE, Embase, and Central for published literature from March 2023 to December 2024.
Microstructure response of concentrated suspensions to flow reversal.
Eur Phys J E Soft Matter
January 2025
Université Paris-Saclay, CNRS, FAST, 91405, Orsay, France.
We study experimentally at the macroscopic and microstructure scale a dense suspension of non-Brownian neutrally buoyant spherical particles experiencing periodic reversals of flow at constant rate between parallel plates and tracked individually. We first characterize the quasi-steady state reached at the end of half periods. The volume fraction of particles increases from the walls to the center as a result of migration induced by the nonuniform strain rate.
View Article and Find Full Text PDFModelling the long-term dynamics and inhibitory effects of crude glycerol impurities in a methanogenic and sulfidogenic UASB bioreactor.
Water Res
January 2025
Department of Civil and Environmental Engineering, University of Florence, Via di S. Marta, 3, 50139, Firenze, Italy.
The performance of Upflow Anaerobic Sludge Blanket (UASB) bioreactors treating sulfate (SO) -rich effluents depends on multiple factors, including microbial interactions and operational conditions. The high complexity of these systems necessitates the use of mathematical modelling tools to better understand the process and predict the long-term impacts of various operational variables. In this work, a mathematical model describing the long-term operation of a sulfate-fed 2.
View Article and Find Full Text PDFParametric Search for Optimal Channel Shape for Swirling Blood Flow in the Heart and Main Vessels.
Dokl Biochem Biophys
January 2025
Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia.
The study presents a numerical parametric investigation of flow structures in channels with a longitudinal-radial profile zR = Const and a spherical dome at the base. The goal of the study was to examine the flow structures in these channels depending on the exponent N of the profile and the height of the dome, to determine the conditions that provide optimal centripetal swirling flow, analogous to blood flow in the heart chambers and major vessels. The investigation was conducted using a comparative analysis of flow structures in channel configurations zR = Const, carried out in two stages.
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