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Dysregulation of mTOR signalling is a converging mechanism in lissencephaly.
Nature
January 2025
Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Cerebral cortex development in humans is a highly complex and orchestrated process that is under tight genetic regulation. Rare mutations that alter gene expression or function can disrupt the structure of the cerebral cortex, resulting in a range of neurological conditions. Lissencephaly ('smooth brain') spectrum disorders comprise a group of rare, genetically heterogeneous congenital brain malformations commonly associated with epilepsy and intellectual disability.
View Article and Find Full Text PDFTherapeutic Targets and Natural Product Screening for Cognitive Impairments Associated with Ferroptosis in Wilson's Disease.
Am J Chin Med
January 2025
Department of Neurology, The First Affiliated, Hospital of Anhui University of Traditional Chinese Medicine, Hefei, P. R. China.
Wilson's disease (WD) is a hereditary condition marked by abnormalities in copper metabolism, which precipitate a spectrum of neurological symptoms and cognitive impairments. Emerging research has highlighted ferroptosis (FPT) as a distinct type of programmed cell death, potentially linked to various cognitive dysfunctions. Nevertheless, the connection between FPT and cognitive impairment in Wilson's disease (WDCI) remains largely enigmatic.
View Article and Find Full Text PDFBiogenic silver nanoparticles synthesized using bracken fern inhibits cell proliferation in HCT-15 cells through induction of apoptosis pathway and overexpression of heat shock proteins.
J Genet Eng Biotechnol
December 2024
Department of Molecular Biology and Genetics, Krishna Vishwa Vidyapeeth "Deemed to be University", Taluka-Karad, Dist-Satara, Pin-415 539, Maharashtra, India.
Article Synopsis
- The study explores the effects of biogenic silver nanoparticles (PR-AgNPs) from the bracken fern Pteridium revolutum on cancer cells, specifically looking at their ability to inhibit cell growth and trigger apoptosis in HCT-15 cells.
- Characterization of the nanoparticles was done using various techniques, revealing they are spherical and sized between 20-40 nm, with significant cell toxicity observed in a dose-dependent manner (IC50 of 5.79 µg/mL).
- Results indicate that PR-AgNPs promote cell death in HCT-15 cells by activating key apoptotic pathways through the expression of genes like p53 and caspase-3.
Anti-carcinogenic effects and mechanisms of actions of fruit peel hydroethanolic extract and limonene in diethylnitrosmine/2-acetylaminofluorene-induced hepatocellular carcinoma in Wistar rats.
Am J Cancer Res
November 2024
Physiology Division, Faculty of Science, Beni-Suef University P.O. Box 62521, Beni-Suef, Egypt.
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death and disability in the world. Citrus species and their constituents have many biological activities including antioxidant, anti-inflammatory and anti-carcinogenic properties. This study aimed to assess the anti-carcinogenic effects and postulate the possible mechanisms of action for Citrus limon fruit peel hydroethanolic extract (CLFPHE) and limonene in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced HCC in male Wistar rats.
View Article and Find Full Text PDFMutational heterogeneity in large B-cell lymphoma: insights from paired biopsies.
Ann Hematol
December 2024
Department of Hematology, Rigshospitalet, Copenhagen, Denmark.
Introduction: Large B-cell lymphoma (LBCL) exhibits striking clinical and molecular heterogeneity. New approaches have emerged to explore tumor heterogeneity and classify LBCL into biological categories. Consequently, the informational requirements from diagnostic samples to provide the necessary information have increased, but the adequacy of single-site biopsies to provide such information is largely unknown.
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