Sophistication of foldamer form and function in vitro and in vivo.

Curr Opin Chem Biol

Department of Chemistry, Yale University, New Haven, CT 06520, USA.

Published: December 2007

AI Article Synopsis

  • Recent advancements in the foldamer field showcase a variety of applications, including cellular penetration and the ability to disrupt membranes.
  • Researchers are focusing on controlling foldamers' complex geometric shapes, which involves their tertiary and quaternary structures.
  • This review highlights significant progress in foldamers and emphasizes the importance of these compounds in maximizing their potential uses.

Article Abstract

Advances in the foldamer field in recent years are as diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the realm of tertiary and quaternary structure. This review will provide recent examples of progress in the foldamer field, highlighting the significance of this class of compounds and the advances that have been made towards exploiting their full potential.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752848PMC
http://dx.doi.org/10.1016/j.cbpa.2007.09.009DOI Listing

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