Advances in the foldamer field in recent years are as diverse as the backbones of which they are composed. Applications have ranged from cellular penetration and membrane disruption to discrete molecular recognition, while efforts to control the complex geometric shape of foldamers has entered the realm of tertiary and quaternary structure. This review will provide recent examples of progress in the foldamer field, highlighting the significance of this class of compounds and the advances that have been made towards exploiting their full potential.
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http://dx.doi.org/10.1016/j.cbpa.2007.09.009 | DOI Listing |
Chemistry
January 2025
Univ Angers, CNRS, MOLTECH-ANJOU-UMR 6226, F-49000, Angers, France.
Helical foldamers constitute particularly relevant targets in the field of host-guest chemistry, be that as hosts or substrates. In this context, the strategies reported so far to control the dimensions and shape of foldamers mainly involve modifications of the skeleton through covalent synthesis. Herein, we prepared an oligopyridine dicarboxamide foldamer substituted by photo-active tetraphenylethylene units (TPE).
View Article and Find Full Text PDFChem Asian J
November 2024
Department of Chemistry, Indian Institute of Technology Guwahati, Assam, 781039, India.
This review highlights important research on anion coordination chemistry for materials applications over the last decade. This field has numerous applications in various areas, such as the environment, industry, and medicine. Despite its enormous potential, real-world applicability is still pending.
View Article and Find Full Text PDFChem Commun (Camb)
November 2024
College of Chemistry Fuzhou University Fuzhou, Fujian 350116, China.
This review is the first to focus on transmembrane transporters derived from aromatic foldamers, with most studies reported over the past decade. These foldamers have made significant strides in mimicking the essential functions of natural ion channel proteins. With their aromatic backbones rigidified by intramolecular hydrogen bonds or differential repulsive forces, this innovative family of molecules stands out for its structural diversity and functional adaptability.
View Article and Find Full Text PDFACS Synth Biol
August 2024
Telescope Scientific Consulting, Richmond, Virginia 23221, United States.
Protein synthesis methods have been adapted to incorporate an ever-growing level of non-natural components. Meanwhile, design of de novo protein structure and function has rapidly emerged as a viable capability. Yet, these two exciting trends have yet to intersect in a meaningful way.
View Article and Find Full Text PDFCurr Opin Chem Biol
August 2024
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:
Metal-dependent enzymes are abundant and vital catalytic agents in nature. The functional versatility of metalloenzymes has made them common targets for improvement by protein engineering as well as mimicry by de novo designed sequences. In both strategies, the incorporation of non-canonical cofactors and/or non-canonical side chains has proved a useful tool.
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