A one-pot method for synthesizing alpha-siloxy-Weinreb amides from aldehydes was developed with use of N,O-dimethylhydroxylamine and a masked acyl cyanide reagent bearing a tert-butyldimethylsilyl group avoiding the competitive reaction toward N-methoxy-N-methyl-2-amino-1-siloxymalononitrile.
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Direct one-pot synthesis of alpha-siloxy-Weinreb amides from aldehydes.
J Org Chem
December 2007
Department of Pharmaceutical Chemistry, Division of Health Biosciences, Graduate School of The University of Tokushima, 1-78-1, Tokushima, Japan 770-8505.
A one-pot method for synthesizing alpha-siloxy-Weinreb amides from aldehydes was developed with use of N,O-dimethylhydroxylamine and a masked acyl cyanide reagent bearing a tert-butyldimethylsilyl group avoiding the competitive reaction toward N-methoxy-N-methyl-2-amino-1-siloxymalononitrile.
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