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What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?
Transpl Int
December 2024
Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich, Germany.
Xenotransplantation of porcine organs has made remarkable progress towards clinical application. A key factor has been the generation of genetically multi-modified source pigs for xenotransplants, protected against immune rejection and coagulation dysregulation. While efficient gene editing tools and multi-cistronic expression cassettes facilitate sophisticated and complex genetic modifications with multiple gene knockouts and protective transgenes, an increasing number of independently segregating genetic units complicates the breeding of the source pigs.
View Article and Find Full Text PDFManagement of heart disease in renal transplant recipients: a national Delphi survey-based SET/SEC/SEN consensus document.
Rev Esp Cardiol (Engl Ed)
October 2024
Servicio de Nefrología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, National Network for Kidney Research RICORS2040 RD21/0005/0012, Instituto de Tecnologías Biomédicas, Universidad de La Laguna, Santa Cruz de Tenerife, Spain. Electronic address:
Renal transplantation improves the survival and quality of life of patients with end-stage renal disease. Cardiovascular disease is the leading cause of morbidity and mortality in renal transplant recipients. The bidirectional relationship between renal and heart disease creates a unique clinical scenario that demands a comprehensive and personalized approach.
View Article and Find Full Text PDFOutcomes of Multiorgan Heart Transplant Between Donation After Circulatory Death and Brain Death.
ASAIO J
October 2024
From the Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Kentucky.
Article Synopsis
- The study investigates the survival outcomes of multiorgan transplants involving heart donations from both donation after circulatory death (DCD) and donation after brain death (DBD) donors.
- A total of 1,844 DBD and 91 DCD heart transplant patients were analyzed, focusing on combinations with other organs like kidneys, livers, and lungs.
- Results showed no significant difference in overall survival rates between DCD and DBD groups, despite longer ischemia times in DCD cases, indicating that DCD organ transplants can be as effective as DBD transplants.
Mechanical support for the treatment of fulminant myocarditis combined with cardiac arrest and MODS in children: A case report and review.
Heliyon
September 2024
Department of Cardiac Surgical Intensive Care Unit, Yantai Yuhuangding Hosptial, Qingdao University Affiliated Hospital, No. 20 of Yuhuangding East Road, Yantai, Shandong, 264000, China.
A 13 years and 1 month old child was admitted to the hospital with fulminant myocarditis. After admission, the child's condition deteriorated rapidly, with a rapid drop in blood pressure, alternating malignant arrhythmias, such as ventricular tachycardia and ventricular fibrillation, and then developed rapid cardiac arrest, which lasted for 62 min. Moreover, the child developed multiple organ failure (heart, kidney, brain, lungs, liver, gastrointestinal tract, and inflammatory system) with internal environmental disturbances, indicating critical conditions.
View Article and Find Full Text PDFIncreasing Multiorgan Heart Transplantations From Donation After Circulatory Death Donors in the United States.
Clin Transplant
August 2024
Division of Cardiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York, USA.
Introduction: Donation after circulatory death (DCD) donors are becoming an important source of organs for heart-transplantation (HT), but there are limited data regarding their use in multiorgan-HT.
Methods: Between January 2020 and June 2023, we identified 87 adult multiorgan-HTs performed using DCD-donors [77 heart-kidney, 6 heart-lung, 4 heart-liver] and 1494 multiorgan-HTs using donation after brain death (DBD) donors (1141 heart-kidney, 165 heart-lung, 188 heart-liver) in UNOS. For heart-kidney transplantations (the most common multiorgan-HT combination from DCD-donors), we also compared donor/recipient characteristics, and early outcomes, including 6-month mortality using Kaplan-Meier (KM) and Cox hazards-ratio (Cox-HR).
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