AI Article Synopsis

  • The study investigated the potential link between mitochondrial DNA haplogroups and tuberculosis (TB) infection, focusing on haplogroups M, N, J, and K.
  • The research compared 54 confirmed TB patients with 256 healthy controls using specific DNA analysis techniques.
  • Results showed no significant differences in the frequency of mitochondrial haplogroups between TB patients and healthy individuals, indicating no association between mtDNA and TB infection.

Article Abstract

Background And Objectives: Mitochondrial DNA has a unique role in ATP production and subsequent mitochondrial reactive oxygen species (ROS) production in eukaryotic cells and there is a potential role for ROS and oxygen burst against Mycobacterium tuberculosis, an intracellular pathogen. This study aimed to determine whether the frequency of different mitochondrial haplogroups was significantly different in patients with tuberculosis (TB) compared with a normal population.

Methods: Mitochondrial DNA haplogroups M, N, J and K were studied by PCR-restriction fragment length polymorphism and sequencing. Cases were 54 patients with confirmed smear positive pulmonary TB. Controls were 256 healthy persons.

Results: There were no statistically significant differences between those with TB and the control group.

Conclusions: There was no statistically significant association between mtDNA haplogroups and the presence of TB infection.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1440-1843.2007.01163.xDOI Listing

Publication Analysis

Top Keywords

mitochondrial dna
12
dna haplogroups
8
mitochondrial
5
haplogroups
4
haplogroups play
4
play role
4
role susceptibility
4
susceptibility tuberculosis?
4
tuberculosis? background
4
background objectives
4

Similar Publications

In vitro fertilization (IVF) is a widely used assisted reproductive technology to achieve a successful pregnancy. However, the acquisition of oxidative stress in embryo in vitro culture impairs its competence. Here, we demonstrated that a nuclear coding gene, methyltransferase-like protein 7A (METTL7A), improves the developmental potential of bovine embryos.

View Article and Find Full Text PDF

Plant mitochondrial genomes (mitogenomes) experience remarkable levels of horizontal gene transfer (HGT), including the recent discovery that orchids anciently acquired DNA from fungal mitogenomes. Thus far, however, there is no evidence that any of the genes from this interkingdom HGT are functional in orchid mitogenomes. Here, we applied a specialized sequencing approach to the orchid Corallorhiza maculata and found that some fungal-derived tRNA genes in the transferred region are transcribed, post-transcriptionally modified, and aminoacylated.

View Article and Find Full Text PDF

Prawns of the genus represent a highly diverse group of high commercial value worldwide. Eight species have been reported from the Peruvian Pacific slope, but their phylogenetic relationships are still unknown. To investigate the systematics of species from Peru, morphological identification and molecular data from nucleotide sequences of three genes were used: cytochrome oxidase subunit I, 16S rRNA, and 28S rRNA.

View Article and Find Full Text PDF

Novel factors of cisplatin resistance in epithelial ovarian tumours.

Adv Med Sci

January 2025

Department of Medical Biology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovak Republic. Electronic address:

Ovarian tumours are these days one of the biggest oncogynecological problems. In addition to surgery, the treatment of ovarian cancer includes also chemotherapy in which platinum preparations are one of the most used chemotherapeutic drugs. The principle of antineoplastic effects of cisplatin (cis-diamminedichloroplatinum(II), CDDP) is its binding to the DNA and the formation of adducts.

View Article and Find Full Text PDF

Circadian rhythms driven by biological clocks regulate physiological processes in all living organisms by anticipating daily geophysical changes, thus enhancing environmental adaptation. Time-resolved serial multi-omic analyses in vivo, ex vivo, and in synchronized cell cultures have revealed rhythmic changes in the transcriptome, proteome, and metabolome, involving up to 50 % of the mammalian genome. Mitochondrial oxidative metabolism is central to cellular bioenergetics, and many nuclear genes encoding mitochondrial proteins exhibit both circadian and ultradian oscillatory expression.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!