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Genomic Study in Opioid-Treated Cancer Patients Identifies Variants Associated With Nausea-Vomiting.
J Pain Symptom Manage
February 2025
Institute for Biomedical Technologies (F.C., F.M.), National Research Council, Segrate, Italy. Electronic address:
Article Synopsis
- Opioids are commonly used to manage cancer pain, but 10%-20% of patients either do not respond well or suffer from negative side effects, potentially due to genetic differences.
- A genome-wide association study (GWAS) was conducted on cancer patients across Europe to find genetic markers related to opioid-induced nausea and vomiting.
- The study identified 65 genetic variants linked to nausea-vomiting scores, including variants in the NPAS2 gene, paving the way for more personalized cancer pain management strategies through further research.
[Rare diseases: unraveling the biological bases to find future therapies].
Medicina (B Aires)
September 2024
Departamento de Neurología Pediátrica, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España. E-mail:
Rare diseases are characterized by low prevalence and high complexity, affecting millions globally. Although technologies like massive sequencing improve diagnose, therapeutic options remain largely symptomatic or palliative, with few curative treatments approved. In the context of rare diseases, especially genetic neurodevelopmental disorders, therapy development faces obstacles such as phenotypic variability, diverse molecular mechanisms, and complexities in assessing neurodevelopment in natural history and clinical trials.
View Article and Find Full Text PDFMoral courage is defined as the courage to act in ethical conflicts based on individual or professional values despite the personal risks involved. Nurses justify their decisions to act morally courageously as part of their ethical decision-making. To describe registered nurses' justifications for acting morally courageously, or not, in ethical conflicts where they needed moral courage.
View Article and Find Full Text PDFThe National Cancer Institute Clinical Trials Planning Meeting to Address Gaps in Observational and Intervention Trials for Cancer-Related Cognitive Impairment.
J Natl Cancer Inst
September 2024
University of Maryland, Baltimore, Baltimore, MD, USA.
Cancer-related cognitive impairment (CRCI) is a broad term encompassing subtle cognitive problems to more severe impairment. CRCI severity is influenced by host, disease, and treatment factors and affects patients prior to, during, and following cancer treatment. The National Cancer Institute (NCI) Symptom Management and Health-Related Quality of Life Steering Committee (SxQoL SC) convened a Clinical Trial Planning Meeting (CTPM) to review the state of the science on CRCI and to develop both Phase II/III intervention trials aimed at improving cognitive function in cancer survivors with non-central nervous system (CNS) disease and longitudinal studies to understand the trajectory of cognitive impairment and contributing factors.
View Article and Find Full Text PDFThe Predicted Outcome of Spinal Cord Stimulation in Patients With a Psychopathological Disorder and Persistent Spinal Pain Syndrome Type 2: A Systematic Review From 2009 to 2021.
Neuromodulation
January 2024
Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Objectives: Psychologic screening is often included as a mandatory component of evaluation of the impact of psychopathology disorders on the predicted outcome of spinal cord stimulation (SCS) for patients with chronic pain due to persistent spinal pain syndrome type 2 (PSPS type 2). The conclusion of such screenings can influence the decision to offer SCS therapy to a patient. However, evidence on the impact of psychopathology on SCS outcomes is still scarce.
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