Value of information analysis in remedial investigations.

Ambio

Geo Innova AB, Solna, Sweden.

Published: September 2007

Site investigations of contaminated land are associated with high costs. From a societal perspective, just enough economic resources should be spent on investigations so that society's limited resources can be used optimally. The solution is to design investigation programs that are cost effective, which can be performed using value of information analysis (VOIA). The principle of VOIA is to compare the benefit at the present state of knowledge with the benefit that is expected after an investigation has been performed. A framework for VOIA of site investigations is presented based on Bayesian risk-cost-benefit decision analysis. The result is an estimate of the value of an investigation program and, for specific problems, the optimal number of samples. The main strength of the methodology is that it promotes clear thinking and compels the decision maker to reflect on issues that otherwise would be ignored. The main weakness is the complexity of VOIA models.

Download full-text PDF

Source
http://dx.doi.org/10.1579/0044-7447(2007)36[486:voiair]2.0.co;2DOI Listing

Publication Analysis

Top Keywords

site investigations
8
analysis remedial
4
investigations
4
remedial investigations
4
investigations site
4
investigations contaminated
4
contaminated land
4
land associated
4
associated high
4
high costs
4

Similar Publications

Development of a novel molecular probe for visualizing mesothelin on the tumor via positron emission tomography.

Eur J Nucl Med Mol Imaging

January 2025

Institute of Radiation Medicine, Fudan University, Xietu Road 2094, Shanghai, 200032, China.

Objectives: Mesothelin (MSLN) is an antigen that is overexpressed in various cancers, and its interaction with tumor-associated cancer antigen 125 plays a multifaceted role in tumor metastasis. The serum MSLN expression level can be detected using enzyme-linked immunosorbent assay; however, non-invasive visualization of its expression at the tumor site is currently lacking. Therefore, the aim of this study was to develop a molecular probe for imaging MSLN expression through positron emission tomography (PET).

View Article and Find Full Text PDF

PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.

View Article and Find Full Text PDF

is a predominant cause of post-operative surgical site infections and persistent bacteremia. Here, we describe a patient who experienced three episodes of infection over a period of 4 months following a total knee arthroplasty. The initial bloodstream isolate (SAB-0429) was a clonal complex 5 (CC5) and methicillin-resistant (MRSA), whereas two subsequent isolates (SAB-0485 and SAB-0495) were CC5 isolates but methicillin-sensitive .

View Article and Find Full Text PDF

Objectives: Many individuals with dementia with Lewy bodies (DLB) die of disease-related complications, but predicting the end of life can be challenging. We identified a phenotype associated with approaching end of life.

Methods: We present 4 exemplar cases where individuals with DLB experienced refractory psychosis before death.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!