Peyronie's disease is a psychologically and physically devastating disorder that is manifest by a fibrous inelastic scar of the tunica albuginea, resulting in palpable penile scar in the flaccid condition and causing penile deformity, including penile curvature, hinging, narrowing, shortening, and painful erections. Peyronie's disease remains a considerable therapeutic dilemma even to today's practicing physicians.
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Treatment with Autologous Adipose-derived Regenerative Cells for Peyronie's Disease in Men: The Straight @head Pilot Study.
Eur Urol Open Sci
January 2025
Clinical Institute, University of Southern Denmark, Odense, Denmark.
Background And Objective: We evaluated the effectiveness of injecting autologous adipose-derived regenerative cells (ADRCs) into plaque in men with chronic Peyronie's disease (PD).
Methods: This pilot safety study recruited 22 Danish men with chronic PD from an outpatient clinic. Patients received one bolus of ADRCs injected into plaque, with follow-ups at 1, 3, 6, and 12 mo.
The Role of the Peyronie's Disease Questionnaire in Translation, Cultural Adaptation, and Treatment Management for Portuguese-Speaking Populations.
Cureus
December 2024
Department of Urology, Faculty of Medicine of São José do Rio Preto, São José do Rio Preto, BRA.
Peyronie's disease (PD) is characterized by the formation of fibrotic plaques within the penile connective tissue, leading to abnormal curvature, pain, and erectile dysfunction, profoundly affecting patients' physical and psychological well-being. The Peyronie's Disease Questionnaire (PDQ) is a validated instrument designed to assess key aspects of the disease, including pain, sexual function, and psychosocial impact. This narrative review underscores the importance of translating and culturally adapting the PDQ into Portuguese to enhance its applicability for Portuguese-speaking populations.
View Article and Find Full Text PDFEffects of therapy in experimental models of Peyronie's disease: a scoping review.
Sex Med
December 2024
Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
Background: Peyronie's disease (PD) is a fibrotic disorder affecting the penile tunica albugínea, with unclear pathophysiology despite centuries of recognition.
Aim: This scoping review maps the effects of interventions in basic PD research, synthesizing evidence from in vivo and in vitro studies to guide future investigation.
Methods: In October-November 2023, a systematic search was conducted across PubMed, Embase (Ovid), Science of Web, and Scopus, following SRYCLE's guidelines.
Penile suspensory ligament: anatomy, function, and clinical perspectives of its repair.
J Sex Med
January 2025
Department of Urology, Holmesglen Private Hospital, Moorabbin 3189, Victoria, Australia.
Background: The penile suspensory ligament (PSL) plays a significant role in penile support and erection and its injury or congenital absence may result in functional impairment of erectile function.
Aim: To describe the diagnosis and surgical repair technique for PSL abnormalities and overall outcomes.
Methods: A comprehensive review of the literature was performed to understand the anatomic relevance of the PSL and historical management of PSL defects.
Purpose Of Review: Peyronie's disease characterizes a condition in which there is angular curvature of the penis. We know that the most patients with Peyronie's disease will not have spontaneous resolution of their penile curvature. As such, patients who desire treatment can elect for either surgical or nonsurgical therapy.
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