POEM, also called nephronectin, is an extracellular matrix protein that is considered to play a critical role as an adhesion molecule in the development and functioning of various tissues, such as kidneys and bones. In the present study, we examined the molecular mechanism of POEM gene expression, and found that transforming growth factor-beta (TGF-beta) strongly inhibited POEM expression in the mouse osteoblastic cell line, MC3T3-E1. TGF-beta-induced decrease of POEM expression occurred in both time- and dose-dependent manners through the activation of TGF-beta receptor I and extracellular signal-regulated kinase/c-Jun N-terminal kinase pathways.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.febslet.2007.10.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Makeup, An Attempt to Reach Eternal Beauty; Plastic Surgeon's View.
J Craniofac Surg
November 2024
Department of Plastic Surgery, Armed Forces Capital Hospital, Bundang-gu, Seongnam, Gyeonggi-do.
In this paper, the authors aim to explore the reasons behind human makeup from both medical and literary perspectives. In a PubMed search for "makeup and cosmetics," 509 titles were identified. Of these, 64 abstracts were reviewed, and ultimately, 8 full texts were referenced.
View Article and Find Full Text PDF"Accepting the Poem of Destiny": Identity Reconstruction in a Chinese Online Depression Community.
Qual Health Res
October 2024
Foreign Studies College, Hunan Normal University, Changsha, China.
Article Synopsis
- - The article examines how online health communities serve as platforms for people with depression to share their experiences, using digital narratives to explore identity reconstruction based on the communication theory of identity (CTI).
- - Members of a Chinese online depression community expressed various identities, categorized into four levels: personal (e.g., "laggard" and "pioneer"), enacted (e.g., "idler" and "fighter"), relational (e.g., "stress-maker" and "escaper"), and communal (e.g., support providers and receivers).
- - The study reveals that these narratives challenge the stigmatized perception of depression by highlighting the complex, multifaceted nature of individuals' experiences, helping them form connections and solidarity within a marginalized community
Beyond the words: Exploring individual differences in the evaluation of poetic creativity.
PLoS One
October 2024
Department of Psychology, Goldsmiths, University of London, London, United Kingdom.
Article Synopsis
- Poetry can make people feel different emotions and think creatively about its meaning.
- This study looked at how certain personality traits, like being open-minded or curious, affect how people judge the creativity of poems.
- The results showed that being open-minded was the most important trait in deciding how creative a poem seemed, alongside factors like how nice it looked and whether it surprised the reader.
Toll-Like Receptor 7-Expressed Macrophages Are Involved in the Pathogenesis of Esophageal Achalasia and Esophagogastric Junction Outflow Obstruction.
Digestion
December 2024
Department of Gastroenterology, Hematology, and Clinical Immunology,, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Introduction: Esophageal achalasia is a typical esophageal motility disorder (EMD). Although viral infections have been hypothesized to play a role in the pathogenesis of esophageal achalasia, its etiology remains unclear. This study used esophageal muscle layer specimens collected during per-oral endoscopic myotomy (POEM) procedures to investigate the association between esophageal achalasia and esophagogastric junction outflow obstruction (EGJOO) and pattern recognition receptors.
View Article and Find Full Text PDFThin-film polarizing beam splitters (PBSs) fulfill a pivotal role in laser beam splitting, modulation, shaping and isolation. In this study, a high-reliability infrared broadband thin-film PBS was developed. To correct for tensile stress in Ge/YbF multilayer coatings, ZnSe compensation layers were incorporated in the multilayer design.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!