The present study (N=40) investigated the time-course of conditioned facilitation of the unconditioned eyeblink reflex (UR). In a single-cue delay classical conditioning procedure, a tone conditioned stimulus (CS) signaled an airpuff unconditioned stimulus (airpuff US) to the eye. A paired group received 40 trials of CS/US presentations with an interstimulus interval (ISI) of 200 ms. An unpaired group received an equal number of explicitly unpaired presentations of the CS and US. Thereafter, eyeblink reflex facilitation was assessed by presenting 94 dB white noise (noise US) 10, 30, 50, 100, 150, and 1000 ms after CS onset. In the paired group, URs were significantly increased as early as 100 ms after CS onset compared to the unpaired group. This reflex facilitation was correlated with CR magnitude, indicating that conditioned facilitation of eyeblink URs indexes an early, automatic, preattentive stage in CR formation.
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