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A Rare Case of Congenital Buccal Lipoblastoma in a Term Neonate.
Cureus
December 2024
Pediatrics/Neonatology, University of Arkansas for Medical Sciences, Little Rock, USA.
A lipoblastoma is a benign tumor of adipocytes originating from embryonic white fat and occurs in the pediatric population. Congenital lipoblastomas, however, are rare, and the incidence of these tumors in neonates is unknown. Due to their rare presentation, congenital oral lipoblastomas can, firstly, pose diagnostic challenges for the pediatrician and must be differentiated from the more commonly seen oral lesions in the newborn and other rare malignant growths.
View Article and Find Full Text PDFArticle Synopsis
- Liposarcomas are the most common type of soft tissue sarcoma, primarily found in deep tissues and the retroperitoneum.
- They include various classifications such as atypical lipomatous tumors, well-differentiated liposarcoma (WDL), dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma.
- DDL is especially common in the retroperitoneum and can have both well-differentiated lipomatous and dedifferentiated components, sometimes resembling other aggressive tumors, and can even differentiate into several other cancer types or form bone tissue.
Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case-control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization.
BMC Cancer
November 2024
Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Article Synopsis
- Lipomatous tumors are the most common soft tissue neoplasms, and distinguishing between benign lipomas and more serious atypical lipomatous tumors requires accurate diagnostic methods, including MDM2/CDK4 immunostaining.
- In a study involving 109 patients, only a small fraction of those diagnosed with atypical tumors tested positive for MDM2, indicating that traditional morphological diagnoses may be unreliable.
- The study highlighted that certain clinical features, such as older patient age and larger tumor size, could help identify potential atypical tumors, even though the overall accuracy of the diagnostic methods assessed was not very high.
Multi-center external validation of an automated method segmenting and differentiating atypical lipomatous tumors from lipomas using radiomics and deep-learning on MRI.
EClinicalMedicine
October 2024
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands.
Article Synopsis
- A study validated a radiomics model that uses MRI imaging to differentiate between lipomas and atypical lipomatous tumors (ALTs), addressing challenges associated with traditional biopsy methods.
- Three cohorts were analyzed: two for external validation from the US and UK and one for prospective validation from the Netherlands, utilizing automatic and interactive segmentation methods for tumor imaging.
- The model demonstrated strong performance with area under the curve (AUC) scores ranging from 0.74 to 0.89, matching or exceeding the diagnostic abilities of expert radiologists.
Laparoscopic two-step abdomino-parasacral resection of a giant pelvic lipoma: a case report.
J Gastrointest Oncol
August 2024
Department of Colorectal Surgery and Oncology (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Pelvic lipomas, particularly when massive in size, present unique surgical challenges due to their intricate anatomical location and proximity to vital structures. Complete resection of tumor is the basic principle. In this case, we demonstrated the complete resection of a huge pelvic lipoma by laparoscopy combined with a transsacral approach, which was rarely reported in the relevant literature.
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