AI Article Synopsis
- The study investigated how resveratrol (RES) protects the heart in rats experiencing heart failure caused by adriamycin (ADR).
- Thirty rats were divided into five groups to measure the effects of different doses of RES compared to a control group, following induction of heart injury from ADR.
- Results showed that RES administration significantly reduced markers of heart damage and displayed dose-dependent protective effects, likely through antioxidant properties and the reduction of nitric oxide levels.
Article Abstract
Objective: To observe the protective effects of resveratrol (RES) on the heart function of the rats with adriamycin-induced heart failure.
Method: Thirty adult male SD rats were randomly divided into 5 groups: normal control (NC) group, adriamycin (ADR) group, RESL + ADR group, RES(H) + ADR group and RES group. RES of 30, 120, 120 mg x kg(-1) x d(-1) was given intraperitoneally (ip) once a day for 3 days in RES(L) + ADR group, RES(H) + ADR group and RES group respectively. The other two groups were given the same amount of normal saline the same way. On the 4h day,ADR of 10 mg x kg(-1) was given intraperitoneally once to induce myocardium injury model. After twenty-four hours, the pathological and biochemical changes of the myocardium were examined.
Result: As compared with NC group, the MDA, NO and NOS of the ADR group were significantly higher (P < 0.05), and the SOD of the ADR group were markedly lower (P < 0.05). As compared with ADR group, the indexes in RES(L) + ADR group, RES(H) + ADR group were exactly opposing, and took on dose dependance (P < 0.05). Light microscopic morphometry of the heart samples of the rats in ADR + RES(L, H) groups revealed typical diminishing of damage.
Conclusion: RES can relieve the toxic effects of ADR on myocardium, and the cardioprotective effects may be correlated with its antioxidant activity and downregulation of NO.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Introduction: Controversy remains regarding transparent cap-assisted technique improves adenoma detection rate (ADR) in colonoscopy. We aimed to investigate the effect of transparent cap-assisted colonoscopy on ADR and other colonoscopy performance.
Methods: We performed sub-analysis of an international, multicenter, open-label database containing colonoscopy data from 11 centers in 4 Asian countries/regions on patients who underwent colonoscopy.
Quantitative Electroencephalography Alpha:Delta Ratio and Suppression Ratio Monitoring During Infant Aortic Arch Reconstruction.
Pediatr Neurol
December 2024
Department of Surgery, University of Rochester Medical Center, Rochester, New York. Electronic address:
Background: During infant aortic arch reconstruction, traditional electroencephalography (EEG) provides only qualitative data limiting neuromonitoring efficacy. Interhemispheric differences in the alpha:delta ratio (ADR) and suppression ratio (SR) measured using quantitative EEG generate numerical trends that may suggest cerebral ischemia. We hypothesized that the ADR and SR during cardiopulmonary bypass (CPB) would correlate with hemodynamics, and that ADR and SR interhemispheric differences would precede neurological injury from infants requiring aortic arch reconstruction.
View Article and Find Full Text PDFThe behavioral characteristics of addiction and mental disorder caused by dextromethorphan abuse were analyzed in multiple dimensions.
Expert Opin Drug Saf
January 2025
Department of ADR Monitoring, Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, Guangdong, China.
Background: The aims of this study were to promote the rational use and supervision of dextromethorphan (DM). This study analyzed serious adverse events such as addiction and mental disorders caused by DM in Shenzhen and the behavioral characteristics of people suspected of abusing DM on the Internet.
Methods: Adverse drug reaction/event (ADR/E) reports from 2017 to 2023 were extracted from the National Pharmaceutical Adverse Reaction Monitoring System database.
[Reversal Roles and Its Mechanism of Asiatic Acid on Multidrug Resistance in K562/ADR Cells Through the Wnt/β-catenin Pathway].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Pediatrics， Binzhou Medical University Hospital， Binzhou 256603, Shandong Province， China.
Article Synopsis
- The study aimed to explore how asiatic acid (AA) affects the drug resistance in human leukemia cells (K562/ADR) resistant to adriamycin (ADR).
- AA was found to reduce the resistance of these cells and enhance the effectiveness of ADR, as shown by various assays including CCK-8 and flow cytometry.
- The results indicated that AA down-regulates the expression of certain proteins related to drug resistance, suggesting a potential mechanism for reversing resistance in these cancer cells.
[Telemedicine and AI-supported diagnostics in the daily routine of visceral medicine].
Chirurgie (Heidelb)
December 2024
Universitätsklinik für Viszeralchirurgie - Pius-Hospital Oldenburg, Universitätsmedizin Oldenburg, Oldenburg, Deutschland.
Advances in telemedicine, exemplified by augmented reality (AR) and virtual reality (VR), are rapidly progressing. For instance, AR available over long distances has already been successfully utilized in crisis intervention, such as in war zones. The potential of telemedicine also appears promising in structurally weak areas or in the involvement of experts in emergency situations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!