Purpose: To investigate whether autonomic impairment post stroke modifies the influence of early aerobic training in relation to resting heart rate, peak workload and walking performance at the subacute stage post event.
Methods: Sixty-four patients after a first ischemic stroke were included and randomly assigned either to an aerobic training or to a control group. The training period lasted 8 weeks. Heart rate variability (HRV) parameters, aerobic and functional abilities were measured.
Results: Early aerobic exercise significantly improved endurance and walking performance in stroke patients (p< 0.05). A significant association was found between the HRV parameters two weeks post event and heart rate at rest and peak workload at the beginning of the program. No significant interaction effects between autonomic impairment and training on outcome measures were found.
Conclusion: Early aerobic training resulted in positive effects on peak workload and walking parameters in stroke patients. No modification effect was found between HRV parameters and exercise on those parameters.
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Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: In this pilot study, the diagnostic agreement for sleep biomarker-based neurodegenerative disorder (NDD) risk probabilities was evaluated in patients with Alzheimer's disease dementia (AD), Lewy body disease (LBD), mild cognitive impairment (MCI), and controls (CG) with a Mini-Mental State Exam scores ≥28.
Methods: Sleep biomarkers recorded with the Sleep Profiler (Advanced Brain Monitoring, Inc.) were used as inputs to a 4-class machine learning algorithm trained to assign NDD risk probabilities to AD=27, LBD=19, isolated REM sleep behavior disorder=15, and CG=58.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Sleep disorders have been associated with cognitive impairment and dementia risk. Measures of autonomic function including baroreflex sensitivity (BRS) and heart rate variability (HRV) have also been associated with sleep quality. The extent to which sleep disorders are linked to autonomic function and alter the risk of Alzheimer's disease (AD) in older adults remains unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: Higher order regulation of autonomic function is maintained by cortical and subcortical interconnected regions within the brain, collectively referred to as the central autonomic network (CAN) (Benarroch, 1993). Despite the well-established relationship between autonomic dysfunction and AD (Femminella et al., 2014) the relationship between CAN functional connectivity and biomarkers of AD, such as Ab ratio, remains unexplored.
View Article and Find Full Text PDFJ Mol Histol
January 2025
School of Stomatology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, 150000, China.
Facial nerve injuries lead to significant functional impairments and psychological distress for affected patients. Effective repair of these injuries remains a challenge. For longer nerve gaps, the regeneration outcomes after nerve grafting remain suboptimal due to limited sources and postoperative immune responses.
View Article and Find Full Text PDFCardiovasc Res
December 2024
Laboratory of Cardiorespiratory Control, Department of Physiology, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O'Higgins 340, Santiago 8331150, Chile.
Aims: Heart failure (HF) is an emerging epidemic worldwide. Despite advances in treatment, the morbidity and mortality rate of HF remain high, and the global prevalence continues to rise. Common clinical features of HF include cardiac sympathoexcitation, disordered breathing, and kidney dysfunction; kidney dysfunction strongly contributes to sodium retention and fluid overload, leading to poor outcomes of HF patients.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!