Leucine treatment (100 mg/kg daily for 5 days) leads to activation of the hepatocyte nuclear system and granular endoplasmic reticulum and to a drastic increase in the number of mitochondria, characterized by polymorphism. In the spleen, Malpighian bodies and periarterial lymphoid sheaths are enlarged, lymphocytes infiltrate the periarterial zone, and the mantle zone is enlarged. In the thymus, the width of the cortical matter shrinks, while that of the medulla increases. The content of lymphocytes in the medulla decreases, while that of Hassal's bodies increases. Unambiguous effects of leucine on the small intestinal morphology (mainly on the villous epithelium) were shown. Goblet cells in the villous epithelium were sharply stenosed because of decreased secretory granules in them.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-007-0067-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phytochemical-Based Drug Discovery for Breast Cancer: Combining Virtual Screening and Molecular Dynamics to Identify Novel Therapeutics.
Chem Biodivers
January 2025
GRT College of Education, Department of Pharmaceutical Chemistry, Tiruttani 631209, Tiruttani, INDIA.
Maternal Embryonic Leucine Zipper Kinase (MELK), a pivotal signaling protein, plays a crucial role in various physiological processes such as cell growth, survival, and differentiation. There is currently a growing interest in MELK as a promising therapeutic target for multiple cancers, including triple-negative breast cancer (TNBC). Exploring MELK as a target offers a prospective strategy to impede cancer progression and enhance the efficacy of conventional anticancer therapies.
View Article and Find Full Text PDFAcute Hyperhidrosis: A Clue to Underlying Autonomic Dysfunction and a Rare Neurological Disorder.
Cureus
December 2024
Internal Medicine, Singapore General Hospital, Singapore, SGP.
Acute hyperhidrosis is characterized by excessive sweating. In the absence of other symptoms, the symptoms of sweating alone are often benign and may be ignored by patients and clinicians. Rarely, hyperhidrosis may be a harbinger of an underlying severe disease.
View Article and Find Full Text PDFVaried Clinical Features and Outcomes of Autoimmune Encephalitis: A Retrospective Case Series.
Cureus
December 2024
Neurology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND.
Introduction: This study discusses the various clinical profiles, investigatory findings, treatment responses, and prognosticating factors in seven cases of autoimmune encephalitis (AE).
Methods: The clinical records of seven AE patients admitted to the Neurology Department, SRM Medical College Hospital and Research Centre, Chennai, from July 2022 to December 2023 were retrospectively analyzed.
Results: The patients' ages ranged from 18 to 35, and all experienced seizures.
Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts.
Reprod Med Biol
January 2025
Laboratory of Animal Breeding and Reproduction, Division of Animal Science, School of Agriculture Utsunomiya University Utsunomiya Tochigi Japan.
Background: In vitro fertilization (IVF) and embryo transfer (ET) are widely used in reproductive biology. Despite the transfer of high-quality blastocysts, the implantation rate of IVF-derived blastocysts remains low after ET.
Methods: This article provides a comprehensive review of current research on embryo implantation regulators and their application to improve the implantation potential of IVF-derived blastocysts.
MC-LR induces and exacerbates Colitis in mice through the JAK1/STAT3 pathway.
J Toxicol Environ Health A
January 2025
Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang, China.
Inflammatory bowel disease (IBD) is a complex gastrointestinal disorder attributed to genetic and environmental factors. Microcystin-leucine-arginine (MC-LR) is an environmental toxin that accumulates in the gut and produces intestinal damage. The aim of this study was to investigate the effects of exposure to MC-LR on development and progression of IBD as well examine the underlying mechanisms of microcystin-initiated tissue damage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!