Effect of HLA-compatibility in married couples on the development and severity of gestosis.

We studied the effect of histocompatibility in married couples on the development and severity of gestosis. It was found that gestosis more often develops in women with two common HLA alleles of class II major histocompatibility complex with her husband. The greatest number of coincidences was detected in subgroups with medium and severe gestosis. Perinatal outcomes in women with medium-severe gestosis having HLA-alleles common with husbands are characterized by delivery of babies with lower body weight.