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Stress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol.

Psychoneuroendocrinology

January 2025

Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium. Electronic address:

Telomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype.

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Cell-free DNA release following psychosocial and physical stress in women and men.

Transl Psychiatry

January 2025

Department of Genetic Psychology, Faculty of Psychology, Ruhr-University Bochum, Universitätsstraße 150, Bochum, Germany.

Cell-free DNA (cfDNA) is continuously shed by all cells in the body, but the regulation of this process and its physiological functions are still largely unknown. Previous research has demonstrated that both nuclear (cf-nDNA) and mitochondrial (cf-mtDNA) cfDNA levels increase in plasma in response to acute psychosocial and physical stress in males. This study further investigated these findings by testing 31 female participants (16 using oral hormonal contraception and 15 not using oral hormonal contraception), and the results were subsequently compared with those of 16 male participants.

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Previous studies suggest that early-life stress (ELS) induced by early maternal separation and isolation (MS) stress during the stress hyporesponsive period (SHRP) leads to increased curiosity-like and increased risky decision-making behaviour in adolescence. Evidence suggests that dietary interventions early in adolescence could play an important role in mitigating the detrimental effects of MS stress on risky decision-making behaviour. Hence, the present study hypothesized that nutritional supplements such as saturated fat (SFA) and/or polyunsaturated fat (PUFA) would be beneficial in ameliorating the impact of MS stress on risky decision-making behaviour when incorporated into the diet during early adolescence.

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Multiprotein bridging factor 1 (MBF1) is a transcription factor family playing crucial roles in plant development and stress responses. In this study, we analyzed MBF1 genes in and under abiotic stresses, revealing evolutionary patterns and functional differences. Four genes were identified in and two in , with conserved MBF1 and HTH domains, similar exon/intron structures, and stress-related -elements in their promoters.

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This study investigates the effects of negative bias temperature (NBT) stress and irradiation on the threshold voltage () of p-channel VDMOS transistors, focusing on degradation, recovery after each type of stress, and operational behavior under varying conditions. Shifts in (Δ) were analyzed under different stress orders, showing distinct influence mechanisms, including defects creation and their removal and electrochemical reactions. Recovery data after each type of stress indicated ongoing electrochemical processes, influencing subsequent stress responses.

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