Studies devoted to the analysis of the mechanisms of packing of collagen fibrils and the effect of the macromolecular structure and the physicochemical parameters of medium on the packing are reviewed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

packing collagen
8
[structural thermodynasmic
4
thermodynasmic aspects
4
aspects packing
4
collagen fibrils]
4
fibrils] studies
4
studies devoted
4
devoted analysis
4
analysis mechanisms
4
mechanisms packing
4

Similar Publications

Suprachoroidal injections are a relatively new method of drug delivery to treat retinal disease. At present, it is difficult to visualize the distribution of injection-delivered product beneath the sclera into the suprachoroidal space. Imaging the suprachoroidal space with OCT is hindered by scattering of light from densely packed collagen fibers of the sclera, limiting depth penetration of the OCT light.

View Article and Find Full Text PDF
Article Synopsis
  • Islet transplantation is a promising treatment for type 1 diabetes but faces challenges due to a shortage of donor organs; this study explores using iPSC-derived insulin-producing cells (IPCs) developed with a new method involving 3D spheroid formation in hydrogel matrices.
  • The research compares the effectiveness of esterified collagen hydrogels against conventional basement membrane extract (BME) hydrogels in improving the differentiation and functionality of IPCs.
  • Results showed that collagen hydrogels significantly enhanced insulin expression, cell interactions, and accelerated IPC differentiation, leading to better insulin secretion in response to glucose compared to traditional methods.
View Article and Find Full Text PDF

The lamina propria (LP) of the urinary bladder lies between the urothelial mucosa and the muscularis propria. This complex stratum is composed of extracellular matrix, several cell types, and collagen types I and III fibers. LP invasion by urothelial carcinoma (progression from stage Ta to T1) is a determinant of bladder cancer advancement.

View Article and Find Full Text PDF

A Collagen Triple Helix without the Super Helical Twist.

bioRxiv

September 2024

Department of Chemistry, Rice University, 6100 Main Street, Houston, TX, 77005, USA.

Collagens are ubiquitous in biology functioning as the backbone of the extracellular matrix, forming the primary structural components of key immune system complexes, and fulfilling numerous other structural roles in a variety of systems. Despite this, there is limited understanding of how triple helices, the basic collagen structural units, pack into collagenous assemblies. Here we use a peptide self-assembly system to design collagenous assemblies based on the C1q collagen-like region.

View Article and Find Full Text PDF

A Novel Biomineralized Collagen Liquid Crystal Hydrogel Possessing Bone-like Nanostructures by Complete In Vitro Fabrication.

Gels

August 2024

National Engineering Research Center for Biomaterials (NERCB), College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.

The microstructure of bone consists of nano-hydroxyapatite (nano-HA) crystals aligned within the interspaces of collagen fibrils. To emulate this unique microstructure of bone, this work applied two biomimetic techniques to obtain bone-like microstructures in vitro, that is, combining the construction of collagen liquid crystal hydrogel (CLCH) with the application of a polymer-induced liquid precursor (PILP) mineralization process. Upon the elevation of pH, the collagen macromolecules within the collagen liquid crystal (CLC) were activated to self-assemble into CLCH, whose fibrils packed into a long and dense fiber bundle in high orientation, emulating the dense-packed matrix of bone.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!