Studies devoted to the analysis of the mechanisms of packing of collagen fibrils and the effect of the macromolecular structure and the physicochemical parameters of medium on the packing are reviewed.
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Suprachoroidal injections are a relatively new method of drug delivery to treat retinal disease. At present, it is difficult to visualize the distribution of injection-delivered product beneath the sclera into the suprachoroidal space. Imaging the suprachoroidal space with OCT is hindered by scattering of light from densely packed collagen fibers of the sclera, limiting depth penetration of the OCT light.
View Article and Find Full Text PDFStem Cell Res Ther
October 2024
Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
Histol Histopathol
September 2024
Department of Pathology, Hadassah Hebrew University Hospital, Jerusalem, Israel.
The lamina propria (LP) of the urinary bladder lies between the urothelial mucosa and the muscularis propria. This complex stratum is composed of extracellular matrix, several cell types, and collagen types I and III fibers. LP invasion by urothelial carcinoma (progression from stage Ta to T1) is a determinant of bladder cancer advancement.
View Article and Find Full Text PDFbioRxiv
September 2024
Department of Chemistry, Rice University, 6100 Main Street, Houston, TX, 77005, USA.
Collagens are ubiquitous in biology functioning as the backbone of the extracellular matrix, forming the primary structural components of key immune system complexes, and fulfilling numerous other structural roles in a variety of systems. Despite this, there is limited understanding of how triple helices, the basic collagen structural units, pack into collagenous assemblies. Here we use a peptide self-assembly system to design collagenous assemblies based on the C1q collagen-like region.
View Article and Find Full Text PDFGels
August 2024
National Engineering Research Center for Biomaterials (NERCB), College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
The microstructure of bone consists of nano-hydroxyapatite (nano-HA) crystals aligned within the interspaces of collagen fibrils. To emulate this unique microstructure of bone, this work applied two biomimetic techniques to obtain bone-like microstructures in vitro, that is, combining the construction of collagen liquid crystal hydrogel (CLCH) with the application of a polymer-induced liquid precursor (PILP) mineralization process. Upon the elevation of pH, the collagen macromolecules within the collagen liquid crystal (CLC) were activated to self-assemble into CLCH, whose fibrils packed into a long and dense fiber bundle in high orientation, emulating the dense-packed matrix of bone.
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