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POLYPHARMACY AND CANCER: А NEW VISION FOR SKIN CANCER PATHOGENESIS-PHOTOTOXICITY AND PHOTOCARCINOGENICITY DUE TO NITROSAMINE CONTAMINATION DURING TELMISARTAN/ TAMSULOSIN INTAKE.
Georgian Med News
November 2024
4Department of Pathology, University of Virginia, Charlottesville, USA.
The toxicokinetics of nitrosamines remain a mystery to this day, though it appears that the role of nitrosamines in potentiating the generation of mutations required for the onset of skin cancer continues to be a significant concern. Nitrosamines are mutagens, genotoxic substances, and mediators of phototoxicity/carcinogenicity, whose long-term daily usage, in the context of polypharmacy, can result in the parallel appearance of heterogeneous forms of skin cancer: keratinocytic and melanocytic. But a number of clinical observations suggest that it is the nitrosamines that potentiate the multiple occurrences of skin cancer over the years, or recurrences of skin cancer localized in areas exposed to solar radiation.
View Article and Find Full Text PDFA randomised cross-over trial assessing the impact of AI-generated individual feedback on written online assignments for medical students.
Med Teach
January 2025
Institute of Medical Education, University Hospital Bonn, Bonn, Germany.
Purpose: Self-testing has been proven to significantly improve not only simple learning outcomes, but also higher-order skills such as clinical reasoning in medical students. Previous studies have shown that self-testing was especially beneficial when it was presented with feedback, which leaves the question whether an immediate and personalized feedback further encourages this effect. Therefore, we hypothesised that individual feedback has a greater effect on learning outcomes, compared to generic feedback.
View Article and Find Full Text PDFA catalytic perspective to nanomaterials reactivity-based toxicity; implications for single- and multiple-component nanomaterials (nanocomposites).
NanoImpact
January 2025
CSIC - Insituto de Catálisis y Petroleoquímica, Madrid, Spain.
The extended use of a given product normally precedes concerns about it. The reactivity-based nanotoxicity is a major concern that must be tackled from its fundamental understanding to its regulatory management. Moreover, concepts and ideas must seamlessly flow between relevant performers.
View Article and Find Full Text PDFSirolimus-coated balloons for peripheral arterial disease: walking free into the future of endovascular treatment.
Cardiovasc Diagn Ther
December 2024
Department of Angiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
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