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Immunocytochemical methods were used to study the population of keratinocytes of interfollicular epidermis in rats under the conditions of morphogenesis, experimentally modified by an application of 13-cis-retinoic acid (0.025% and 0.05% solutions for two weeks). The treatment resulted in the increase of the number of PCNA+ and Ki-67+ nuclei in the epidermis and of the thickness of epithelial cell layer, not involved in cytokeratin 10 synthesis.
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