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How Dendrimers Impact Fibrin Clot Formation, Structure, and Properties.
ACS Omega
December 2024
Department of Biochemistry, Federal University of São Paulo, São Paulo, SP 04044-020, Brazil.
Polyamidoamine (PAMAM) dendrimers, with their unique structural versatility and tunable surface functionalities, have emerged as promising nanomaterials for a wide range of biomedical applications. However, their in vivo use raises concerns, as unintended interactions between dendrimers and blood components could disrupt the delicate hemostatic balance and lead to serious complications like bleeding or thrombosis. In this study, we explored the impact of low-generation PAMAM dendrimers on the kinetics of fibrin clot formation, along with their influence on the structure, properties, and resistance to lysis of the resulting clots.
View Article and Find Full Text PDFImpact of increasingly complex cell culture conditions on the proteome of human periodontal ligament stem cells.
Regen Med
January 2025
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Aims: Human periodontal ligament stem cells (hPDLSCs) exhibit an enormous potential to regenerate periodontal tissue. However, their translatability to the clinical setting is constrained by technical difficulties in standardizing culture conditions. The aim was to assess complex culture conditions using a proteomic-based protocol to standardize multi-layer hPDLSC cultivation methodology.
View Article and Find Full Text PDFA nomogram predicting the risk of venous thromboembolism in patients following urologic surgeries.
Sci Rep
January 2025
Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing, 100000, China.
There are inconsistent results pertaining to risk factors for venous thromboembolism (VTE) in patients following urologic surgeries. We attempted to establish a visualization model to shed further light upon this topic. Consequently, a total of 436 patients who were tested for VTE following urologic surgeries were retrospectively enrolled.
View Article and Find Full Text PDFRobot-Assisted Laparoscopic Application of Fibrin Sealant Patch for Repair of Inferior Vena Cava.
CRSLS
January 2025
Northwell Health-Lenox Hill Hospital, New York, NY. (Drs. Chu, Alden, and Seckin).
Introduction: There is a risk of iatrogenic vascular injuries during robotic-assisted laparoscopic excision of diaphragmatic endometriosis. Although studies are limited, the first reported case of a suprahepatic inferior vena cava (IVC) injury during robotic diaphragmatic endometriosis excision was successfully treated using a fibrin sealant patch, preventing exsanguination and conversion to laparotomy.
Case Description: A 36-year-old female with a history of recurrent catamenial pneumothorax and two prior video-assisted thoracoscopic surgeries to treat diaphragmatic endometriosis presented to our clinic with right-sided shoulder pain and a chest tube in place.
Platelet-rich fibrin application after mandibular third molar extraction: an umbrella review.
Clin Oral Investig
December 2024
Department of Stomatology, First Branch Hospital of First Affilliated Hospital, Chongqing Medical University, Chongqing, China.
Objectives: The aim of this study was evaluate the effect of Platelet-Rich Fibrin (PRF) in patients after mandibular third molar extraction through an analysis of the most current literature on systematic reviews and meta-analyses.
Data, Sources And Study Selection: By using computer-assisted search technology, we comprehensively searched several reliable databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data, the Chinese biomedical literature database, PubMed, Web of Science, EMBase, and the Cochrane Library, and performed a systematic retrospective meta-analysis on all of the collected studies on the therapeutic effects of PRF on patients after mandibular third molar extraction. A total of nine meta-analyses were performed in this study, and all nine studies were rated as high quality on the basis of the AMSTAR 2 criteria.
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