AI Article Synopsis
- The study analyzed data from 700 patients who underwent surgery for colorectal liver metastases between 1993 and 2006, focusing on their outcomes and survival rates.
- The median patient age was 64, with a 5-year survival rate of 45%, influenced by the number of metastases and the presence of an inflammatory response to the tumor.
- A preoperative prognostic score was developed, categorizing patients based on metastases and inflammatory status, which effectively predicted 5-year survival rates: scoring 0 had a 49% survival, scoring 1 had 34%, and those scoring 2 had no survivors.
Article Abstract
Background: Despite indications for resection of colorectal liver metastases having expanded, debate continues about identifying patients that may benefit from surgery.
Methods: Clinicopathologic data from a total of 700 patients was gathered between January 1993 and January 2006 from a prospectively maintained dataset. Of these, 687 patients underwent resection for colorectal liver metastases.
Results: The median age of patient was 64 years and 36.8% of patients had synchronous disease. The overall 5-year survival was 45%. The presence of an inflammatory response to tumor (IRT), defined by an elevated C-reactive protein (>10 mg/L) or a neutrophil/lymphocyte ratio of >5:1, was noted in 24.5% of cases. Only the number of metastases and the presence or absence of an IRT influenced both overall and disease-free survival on multivariable analysis. A preoperative prognostic score was derived: 0 = less than 8 metastases and absence of IRT; 1 = 8 or more metastases or IRT, and 2 = 8 or more metastases and IRT-from the results of the multivariable analysis. The 5-year survival of those scoring 0 was 49% compared with 34% for those scoring 1. None of the patients that scored 2 were alive at 5 years.
Conclusion: The preoperative prognostic score is a simple and effective system allowing preoperative stratification.
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| http://dx.doi.org/10.1097/SLA.0b013e318142d964 | DOI Listing |
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