Aims: To examine the extent and impact on clinical outcomes of adherence to electrocardiogram (ECG) entry criteria in ST-elevation myocardial infarction patients in the assessment of pexelizumab in acute myocardial infarction (APEX-AMI) trial.
Methods And Results: We examined the frequency, characteristics, and outcomes of patients enrolled in APEX-AMI trial who did not meet the trial ECG entry criteria. Among 5615 patients analysed, 28.8% did not meet ECG entry criteria: this occurred more than twice as frequently amongst those with high-risk inferior vs. those with other MI (42.3 vs. 19.3%, P < 0.001). Regardless of infarct location, patients who failed to meet ECG entry criteria had significantly lower mortality (2.5 vs. 4.5% at 30 days and 3.1 vs. 5.3% at 90 days; both P < 0.001) and the composite rate of death, cardiogenic shock, or CHF (5.8 vs. 10.3% at 30 days and 6.9 vs. 11.4% at 90 days; both P < 0.001) as compared to those who met criteria.
Conclusion: In APEX-AMI over one-quarter of enrolled patients did not meet ECG entry criteria and had better outcomes than eligible patients. Although the trial's primary result was unaffected by alignment with the baseline ECG criteria, our findings may have important implications in designing future trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/eurheartj/ehm453 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction: Available therapies for peripheral nerve injury (PNI) include surgical and non-surgical treatments. Surgical treatment includes neurorrhaphy, grafting (allografts and autografts) and tissue-engineered grafting (artificial nerve guide conduits), while non-surgical treatment methods include electrical stimulation, magnetic stimulation, laser phototherapy and administration of nerve growth factors. However, the treatments currently available to best manage the different PNI manifestations remain undetermined.
View Article and Find Full Text PDFEating- and Weight-Related Disorders in the Armed Forces.
Metabolites
December 2024
Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Background/objectives: Like in the general population, the prevalences of eating- and weight-related health issues in the armed forces are increasing. Relevant medical conditions include the eating disorders (EDs) anorexia nervosa, bulimia nervosa, binge eating disorder, and avoidant restrictive food intake disorder (ARFID), as well as body dysmorphic disorder, muscle dysmorphia, and the relative energy deficiency in sport (RED-S) syndrome.
Methods: We performed a narrative literature review on eating- and weight-related disorders in the armed forces.
ON THE ISSUE OF RADON EXPOSURE IN THE EXISTING RADIATION SITUATION AT WORKPLACES.
Probl Radiac Med Radiobiol
December 2024
State Institution «O.M. Marzіeiev Institute for Public Health of the National Academy of Medical Sciences of Ukraine», 50 Hetman Pavlo Polubotok Str., Kyiv, 02094, Ukraine.
Objective: assessment of probable exposure levels from radon and NORM in workplaces within the context of justi fying radiation protection plans in an existing exposure situation.
Materials And Methods: Materials regarding the assessment of naturally occurring radioactive material (NORM) con tent in tailing from mining and processing industries in Ukraine and assessments of contamination levels of industri al sites of oil and gas enterprises were used for estimating the probable range of effective doses (ED) of workers fromNORM at industrial enterprises. These materials were obtained as a result of research conducted by specialists from theRadiation Protection Laboratory of the State Institution «O.
Development of the Revised Entry-Level Essential Competencies in the Care of Older Adults: Linking Domains of Competence, Commission on Accreditation in Physical Therapy Education Standards, and the Geriatric 5Ms.
J Geriatr Phys Ther
December 2024
Division of Physical Therapy, University of Central Florida, Orlando, Florida.
Purpose: Geriatric physical therapy (PT) has evolved since 2011, when the Essential Competencies (ECs) in the Care of Older Adults at the Completion of the Entry-level Physical Therapy Professional Program of Study were published. The purpose of the ECs was to ensure that all entry-level physical therapists were prepared to meet the unique needs of the growing older adult population. Changes in population demographics, medical and research advances, coupled with advancements in the profession of PT, necessitate a revision of the ECs.
View Article and Find Full Text PDFWhat If…The Impact of Institutional Accreditation on PA Programs Transitioning to an Entry-Level Professional Doctorate Degree.
J Physician Assist Educ
December 2024
Jennifer A. Snyder, PhD, PA-C, DFAAPA, is a professor, Physician Assistant Program, Associate Dean, College of Pharmacy and Health Sciences, Butler University, 4600 Sunset Avenue, Indianapolis, Indiana.
Introduction: There are several ramifications of a potential degree transition to an entry-level doctoral degree for Physician Assistant (PA) programs. The purpose of this article is to investigate the impact on institutional accreditation and transitioning to an entry level doctoral degree. To understand the potential impact on racial diversity, a subset of programs was further reviewed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!