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Effect of strontium ranelate on fracture healing in rat tibia. | LitMetric

Effect of strontium ranelate on fracture healing in rat tibia.

Joint Bone Spine

Gaziantep University Faculty of Medicine, Orthopedic and Traumatology Department, 27060 Gaziantep, Sahinbey, Turkey.

Published: December 2007

AI Article Synopsis

  • The study aimed to evaluate the effect of strontium ranelate on fracture healing in rat tibias, leveraging its unique dual-action anti-osteoporotic properties.
  • Forty-two Wistar rats were divided into two groups, one receiving a diet with strontium ranelate and the other a regular diet, after undergoing a tibial fracture.
  • Results showed that while fracture healing occurred in both groups over time, there were no significant differences in healing outcomes between the strontium ranelate group and the control group.

Article Abstract

Objectives: Various anti-osteoporotic agents are available for clinical use. In contrast to other anti-osteoporotic drugs, strontium ranelate has anti-resorptive and bone-forming effects (dual action). Our objective in the present study is to investigate the efficacy of strontium ranelate (SR) on fracture healing in rat tibia.

Methods: Forty-two male Wistar rats randomized into two groups (groups 1 and 2, n=21 for each). Left tibiae of all animals were broken in a closed manner using a manual three-point bending technique through mid-tibia following deep anesthesia with ketamine. The animals in group 1 were fed 25g/day specially produced food containing 450mg/kg SR starting from the first post-operative day. Group 2 were given 25g/day normal food. The animals were sacrificed on the 2nd, 3rd and 4th post-operative weeks (each week 7 animals were sacrificed from each group) and the broken tibiae were removed. The tibiae were examined first radiographically and second, histopathologically.

Results: Radiologically, callus maturity and bone union increased with time in both groups. But no significant differences were found regarding callus maturity and bone union in weekly comparisons (p=0.52, p=0.19, p=0.74).

Conclusions: Histopathologically, it was seen that the fractures remarkably healed steadily in both groups on the 2nd, 3rd and 4th post-operative weeks. But no significant differences were found regarding the progression of fracture callus in weekly comparison (p=1.0, p=0.52, p=1.0). In the present study, we were unable to find any beneficial or harmful effects of strontium ranelate on fracture healing.

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Source
http://dx.doi.org/10.1016/j.jbspin.2007.01.034DOI Listing

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