The exploration and description of the new cytokine system of tumor necrosis factor (TNF) superfamily contributed to different look on the biology of the bone tissue cells. The OPG/RANKL/RANK system constitutes the important element of controlling the number of active osteoclasts by the osteoblasts. It is essential to determine the influence of age and dependence among osteoprotegerin (OPG) and the level of sex hormones, biochemical markers of bone turnover and other factors in the metabolism of bone tissue in the state of physiology and pathophysiology.
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