Unlabelled: Dysfunction of the lens due to opacification is called cataract. Senile cataract is associated with old age. It is estimated that the need for cataract extractions would be diminished by half if onset of cataract would be delayed by only ten years. It thus appears crucial to have a better characterization of the etiology of cataract to detect modifiable factors. It seems that oxidative stress may play an important role in cataractogenesis. Also, it was demonstrated that some plasma constituents correlate with human cataract location.
Objective: We supposed that in senile cataract the oxidative insult may be systemic and not only at the lens level. The aim of our study was to evaluate the blood redox status in cataractous patients aged between 50-65.
Design And Methods: The blood samples were collected from 15 patients with pure nuclear cataract and/or posterior subcapsular cataract, without metabolic or somatic diseases and from 15 age and sex matched controls. Carbonyl content of plasma proteins was evaluated with 2,4-dinitro-phenyl-hydrazine method. The a-oxoaldehydes were measured in the presence of Girard T reactive. The lipid peroxides concentration was assessed measuring malondialdehyde concentration using thiobarbituric acid. For the other plasma parameters we used kits.
Results: The levels of plasma protein carbonyls and malondialdehyde were significantly increased in the cataract group. The plasma levels of: total proteins, globulins, total thiols, fasting glucose, triglycerides and alpha-oxoaldehydes were not modified comparing the groups. Plasma concentrations of albumin and cholesterol were significantly decreased.
Conclusion: The study underlies the presence of an increased plasma oxidative stress in cataractous patients. The abnormal oxidative stress parameters are linked to the premature development of senile cataract. Preventive therapy in order to delay the onset of senile cataract requires more research work on plasma oxidative stress markers.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The Effect of Cataract Surgery on Stereoacuity, Balance, and Falls in Patients With Senile Cataract.
Eye Contact Lens
January 2025
Department of Ophthalmology (O.O.), Niğde Ömer Halisdemir University, Niğde, Turkey; Department of Ophthalmology (O.D.), Mersin University, Mersin, Turkey; Department of Ophthalmology (P.E.), Tarsus State Hospital, Mersin, Turkey; and Department of Ophthalmology (E.S.G.), Mersin State Hospital, Mersin, Turkey.
Objectives: To investigate the effect of cataract surgery on visual acuity, stereoacuity, balance, and falls in patients with senile cataract.
Methods: Prospective, cross-sectional study. The patients were divided into group 1 if the first surgery was performed on the dominant eye and group 2 on the nondominant eye.
A decade of intracapsular cataract extraction: Clinical profile and visual outcomes at Hospital Melaka, Malaysia.
Med J Malaysia
January 2025
Universiti Sains Malaysia, School of Medical Sciences, Department of Ophthalmology and Visual Science, Health Campus, Kubang Kerian, Kelantan, Malaysia.
Introduction: Cataract is a leading cause of visual impairment globally and in Malaysia, with surgery being the definitive treatment. While intracapsular cataract extraction (ICCE) is now less commonly performed due to advancements in surgical techniques, it remains essential in specific cases, such as those with weak zonular support. This study aims to evaluate the incidence, clinical profiles, and visual outcomes of patients who underwent ICCE, with or without intraocular lens (IOL) implantation, at Hospital Melaka, Malaysia, over the past decade.
View Article and Find Full Text PDF[Peculiarities of the time of manifestation of a number of diseases in the periods before and after the COVID-19 pandemic according to the data of municipal polyclinics of Sakhalin region.].
Adv Gerontol
January 2025
Research Medical Centre «Gerontology», 116, 1, 321 Volokolamskoe highway, Moscow 125371, Russian Federation.
The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.
View Article and Find Full Text PDFEvaluation of change in the contact of IOL with the posterior capsule with respect to the orientation of haptics of the IOL using intraoperative spectral domain optical coherence tomography.
Indian J Ophthalmol
December 2024
University Eye Clinic Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
Purpose: To study change in the contact of intraocular lens (IOL) with the posterior capsule with respect to the vertical versus horizontal orientation of the haptic-optic junction of the IOL using intraoperative spectral domain optical coherence tomography (SD-OCT).
Methods: Fifty eyes of 50 patients with senile immature cataract underwent topical phacoemulsification procedure with implantation of a monofocal IOL by a single experienced surgeon. The Rescan 700 SD-OCT system was used for intraoperative imaging.
Genotypic and phenotypic analysis of an oculocutaneous albinism patient: a case report and review of the literature.
J Med Case Rep
December 2024
Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital, Northwest University, Xi'an, 710004, Shaanxi, China.
Background: Oculocutaneous albinism is a rare autosomal recessive disorder caused by congenital melanin deficiency, resulting in hypopigmentation of the eyes, hair, and skin. This study included a Chinese family with an oculocutaneous albinism pedigree, in which the proband presented with oculocutaneous albinismcombined with secondary angle closure, which has been rarely reported in previous literature. This article primarily focused on the clinical and genetic examination results of this patient and provided recommendations for ophthalmologist to treat patients with oculocutaneous albinism in clinical practice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!