This study is intended to describe the cancer-related hospitalisations in the thirty French University and Regional Hospitals (CHR&U). The analysis is carried out on the years 2001 and 2002 databases and uses a relevant PMSI (Medicalisation Program Information System, the French DRG) data analysis program, which is an adapted version of the DAC (Cancer Activity Description) analysis program. Cases are selected from cancer-related diagnoses and procedures. The results provided have been classified according to paediatric and adult populations, to the organ anatomical localisations and to the different types of care : one-day hospitalisations or hospitalisations of more than one day, medical or surgical care, cares which include chemotherapy, radiation therapy or palliative procedures. Cancer-related hospitalisations amount to almost 25 % of the total CHR&U hospitalisations and add up to over a million stays per year. One-day hospitalisations amount to 25% of the cancer-related stays and essentially consist in radiation therapy (50% within the adult category) and for chemotherapy (30%). 26% of the hospitalisations of more than one day are surgical. This study is a first descriptive analysis of cancer-related hospital activity in CHR&U. The next stage will see this analysis applied to patients, using the anonymous patient identification number contained in the PMSI coding.
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Am J Surg Pathol
January 2025
Department of Pathology, Johns Hopkins University, Baltimore, MD.
Low-grade gliomas and reactive piloid gliosis can present with overlapping features on conventional histology. Given the large implications for patient treatment, there is a need for effective methods to discriminate these morphologically similar but clinically distinct entities. Using routinely available stains, we hypothesize that a limited panel including SOX10, p16, and cyclin D1 may be useful in differentiating mitogen-activated protein (MAP) kinase-activated low-grade gliomas from piloid gliosis.
View Article and Find Full Text PDFChem Biodivers
January 2025
Guizhou Medical University, School of Pharmaceutical Sciences, University Town, Gui'an New District, 550025, Guiyang, CHINA.
An unrevealed dihydroflavone-monoterpene conjugate (1), two unrevealed kavalactones (2-3, including one with an uncommon side chain), and thirteen previously identified compounds (4-16) were extracted from Alpinia katsumadai Hayata. seeds. The two-dimension structures of the new compounds were authenticated utilizing HRESIMS as well as NMR spectral analysis, while their absolute chiral configurations were ascertained either by correlating the experimental and simulated values of electronic circular dichroism (ECD) patterns or conducting X-ray diffraction experiments.
View Article and Find Full Text PDFBackground And Aim: The high rate of tumor growth results in an increased need for amino acids. As solute carriers (SLC) transporters are capable of transporting different amino acids, cancer may develop as a result of these transporters' over-expression due to their complex formation with other biological molecules. Therefore, this review investigated the role of SLC transporters in the progression of cancer.
View Article and Find Full Text PDFCureus
December 2024
Department of Radiology, University of Medicine and Pharmacy of Craiova, Craiova, ROU.
Background: Cervical cancer is considered one of the most common gynecological malignancies with an increased incidence in developing countries. Magnetic resonance imaging (MRI) plays a valuable role in staging cervical cancer and providing valuable information necessary for selecting the appropriate treatment plan, while closely correlating with the prognosis of the patient.
Objective: The aim of this study is to assess the diagnostic value of diffusion-weighted imaging (DWI) in the preoperative loco-regional staging of cervical carcinoma.
Mol Ther Nucleic Acids
March 2025
Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA 22903, USA.
The CDKN2A gene, responsible for encoding the tumor suppressors p16(INK4A) and p14(ARF), is frequently inactivated in non-small cell lung cancer (NSCLC). Herein, an uncharacterized long non-coding RNA (lncRNA) (ENSG00000267053) on chromosome 19p13.12 was found to be overexpressed in NSCLC cells with an active, wild-type CDKN2A gene.
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