AI Article Synopsis
- Lithium administration in rats led to notable changes in sleep patterns, especially a significant reduction in REM sleep.
- It impacted autonomic functions, including lowering cAMP levels in the preoptic-anterior hypothalamic region, while increasing IP(3) concentration in the cerebral cortex under low temperature conditions.
- The study highlights that sleep disturbances are among the earliest effects of lithium, with varied biochemical responses observed based on brain region and environmental factors.
Article Abstract
The effects of a single intraperitoneal administration of lithium, a drug used to prevent the recurrence of mania in bipolar disorders, were determined in the rat by studying changes in: (i) the wake-sleep cycle; (ii) autonomic parameters (hypothalamic and tail temperature, heart rate); (iii) the capacity to accumulate cAMP and IP(3) in the preoptic-anterior hypothalamic region (PO-AH) and in the cerebral cortex (CC) under an hypoxic stimulation at normal laboratory and at low ambient temperature (T(a)). In the immediate hours following the injection, lithium induced: (i) a significant reduction in REM sleep; (ii) a non-significant reduction in the delta power density of the EEG in NREM sleep; (iii) a significant decrease in the concentration of cAMP in PO-AH at normal laboratory T(a); (iv) a significant increase of IP(3) concentration in CC following exposure to low T(a). The earliest and most sensitive effects of lithium appear to be those concerning sleep. These changes are concomitant with biochemical effects that, in spite of a systemic administration of the substance, may be differentiated according to the second messenger involved, the brain region and the ambient condition.
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| http://dx.doi.org/10.1016/j.bbr.2007.09.017 | DOI Listing |
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