Infections by Chlamydia psittaci are found worldwide in many species of mammal, including man, and birds. Small ruminants are affected mainly with abortion in the later phase of gestation. Additionally pneumonia and lesions in other organs can be observed. Pathological and clinico-epidemiological aspects of the infection with C. psittaci in small ruminants are described and discussed. The description of a case of conjunctivitis acquired by one of the authors through contact with infectious material alerts to the significance of C. psittaci as an agent able to cause zoonotic infections.
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Sci Rep
January 2025
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Medical Center - University of Freiburg, University of Freiburg, Freiburg, Germany.
This experimental phantom study investigates current standard of care protocols in cone beam computed tomography (CBCT), energy-integrating-detector (EID) CT, and photon-counting-detector (PCD) CT regarding their potential in delineation of dental root canals. Artificial accessory canals (diameters: 1000, 600, 400, 300 and 200 μm) were drilled into three bovine teeth mounted on a bovine rib as a jaw substitute. The phantom was scanned in two dental CBCTs, two EID-CTs and a PCD-CT using standard clinical protocols.
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January 2025
Division of Hematology and Oncology, University of California, 1450 3rd Street, San Francisco, CA, 94143, USA.
For individuals at high risk of developing breast cancer, interventions to mitigate this risk include surgical removal of their breasts and ovaries or five years treatment with the anti-estrogen tamoxifen or aromatase inhibitors. We hypothesized that a silicone based anti-estrogen-eluting implant placed within the breast would provide the risk reduction benefit of hormonal therapy, but without the adverse effects that limit compliance. To this end, we demonstrate that when placed adjacent to mammary tissue in the 7,12-dimethylbenz[a]anthracene-induced rat breast cancer model a fulvestrant-eluting implant delays breast cancer with minimal systemic exposure.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Pathology, University of California San Diego, La Jolla, CA 92093.
We hypothesized that a strategy employing tissue-specific endothelial cells (EC) might facilitate the identification of tissue- or organ-specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify water-soluble small molecules with mitogenic activity on choroidal EC. We identified adenosine diphosphate (ADP) as a candidate, following biochemical purification from mouse EL4 lymphoma extracts.
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January 2025
Veterinary Epidemiology, Economics and Public Health Group, WOAH Collaborating Centre for Risk Analysis and Modelling, Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, UK.
The World Health Organization describes brucellosis as one of the world's leading zoonotic diseases, with the Middle East a global hotspot. Brucella melitensis is endemic among livestock populations in the region, with zoonotic transmission occurring via consumption of raw milk, amongst other routes. Control is largely via vaccination of small ruminant and cattle populations.
View Article and Find Full Text PDFJ Infect Dev Ctries
December 2024
Department of Veterinary Medicine, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus, Palestine.
Introduction: Peste des petits ruminants (PPR) is a highly contagious and fatal disease affecting small ruminants, particularly goats and sheep, and is caused by Morbillivirus caprinae, a virus in the genus Morbillivirus, family Paramyxoviridae. PPR has significant economic and social impacts, especially in Africa, Asia, and the Middle East, where small ruminants are vital to rural livelihoods and food security. This disease is a priority for global eradication due to its disproportionate impact on low-income farmers and wildlife conservation.
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