AI Article Synopsis
- The study investigates how acute ethanol affects the expression of certain genes related to brain function in rats.
- Ethanol administration led to increased expression of the tyrosine hydroxylase and proenkephalin genes in specific brain regions, indicating heightened neural activity.
- Conversely, there was a notable decrease in the expression of the cannabinoid CB1 receptor gene, suggesting that ethanol induces changes that may enhance the rewarding effects associated with its consumption.
Article Abstract
The aim of this study was to examine the differential regulation after acute ethanol administration on tyrosine hydroxylase, proenkephalin and cannabinoid CB(1) receptor gene expressions in selected areas of the rat brain. Rats received an intragastric administration of 3 g/kg ethanol and were killed by decapitation at 1, 2, 4, 8 and 24 h. The results showed an activation of tyrosine hydroxylase gene expression in the ventral tegmental area and the substantia nigra, increased proenkephalin gene expression in the caudate-putamen, nucleus accumbens core and shell, central and medial amygdala, ventromedial hypothalamic nucleus and the paraventricular hypothalamic nucleus. In contrast, a significant decrease in the cannabinoid CB1 receptor gene expression was found in caudate-putamen, central amygdala and ventromedial hypothalamic nucleus. In conclusion, the results suggest that an acute dose of ethanol induces neuroplastic alterations in proenkephalin, tyrosine hydroxylase and cannabinoid CB1 receptor gene expressions that may contribute to trigger the rewarding effects of ethanol consumption.
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| http://dx.doi.org/10.1016/j.euroneuro.2007.09.001 | DOI Listing |
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