AI Article Synopsis
- The study aimed to identify the parental origin of complete hydatidiform moles by examining 9 specific loci of microsatellite polymorphisms.
- Researchers utilized multipolymerase chain reaction and advanced DNA analysis techniques on 50 diagnosed cases and samples from the couples.
- The results showed that 86% of the cases were androgenetic moles, while 14% were biparental, highlighting the effectiveness of microsatellite detection in determining parental origins in these conditions.
Article Abstract
Objective: Through detection of 9 loci of polymorphisms of microsatellite to investigate the parental origin of complete hydatidiform mole.
Methods: Using the technology and method of multipolymerase chain reaction and electrophoresis in denatured polyacrylamide gel and silver stain detection, we carried out DNA analysis on 50 cases of complete hydatidiform mole diagnosed by histopathology and 50 copies of the couples' peripheral blood.
Results: There are 7 cases of biparental complete hydatidiform mole (14%); and 43 cases of androgenetic complete hydatidiform mole (86%) among 50 cases of complete hydatidiform mole.
Conclusions: Detection of polymorphisms of microsatellite is a technology that can be used to identify the parental origin of complete hydatidiform mole. It is simple, quick, reliable and highly efficient.
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