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This paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang's Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed the SAS macro programme %BBIplus to facilitate the implementation of BBI. This user-friendly programme allows for easy and rapid estimation and visualisation of BBI across different scenarios, including pairwise comparison RCTs with two arms, double-dummy design RCTs with three arms and factorial design RCTs with four arms.
View Article and Find Full Text PDFDifferentiating Depressive Symptoms From Side Effects in Individuals With Major Depressive Disorder With Postpartum Onset.
J Clin Psychopharmacol
December 2024
Developing Brain Institute, Children's National Hospital, George Washington University, Washington, DC.
Article Synopsis
- Somatic symptoms, often seen in postpartum major depressive disorder, can mimic antidepressant side effects, prompting this study to explore their correlation with depressive symptom declines measured by specific scales.
- This research involved a secondary analysis of a previous trial with 62 participants, comparing the effects of sertraline and estradiol against placebos over 8 weeks, focusing on symptoms tracked by the SIGH-ADS and Asberg scales.
- Results showed a positive correlation between decreases in both depressive and somatic symptoms, highlighting the need to differentiate between true side effects and symptoms of the underlying condition in postpartum treatment.
Background Patients with irritable bowel syndrome (IBS) often experience chronic abdominal pain and bowel habit changes, with a heightened risk of depression and anxiety compared to the general population. Methods Using TriNetX data from 61 U.S.
View Article and Find Full Text PDFImpact of the use of a drug-drug interaction checker on pharmacist interventions involving well-known strong interactors.
Eur J Hosp Pharm
December 2024
Institut de Pharmacie, Lille, France.
Objectives: Several drug-drug interaction (DDI) checkers such as DDI-Predictor have been developed to detect and grade DDIs. DDI-Predictor gives an estimate of the magnitude of an interaction based on the ratio of areas under the curve. The objective of the present study was to analyse the frequencies of DDIs involving well-known strong interactors such as rifampicin and selective serotonin reuptake inhibitors (SSRIs), as reported by a clinical pharmacy team using DDI-Predictor, and the pharmacist intervention acceptance rate.
View Article and Find Full Text PDFEvaluation of comparative efficacy of capsule versus sertraline capsule in the management of (generalized anxiety disorder): protocol for a randomized controlled trial.
F1000Res
October 2024
Department Kayachikitsa, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
Background: Generalized anxiety disorder (GAD) is one among many types of mental disorders explained in Ayurveda. It can be defined as a (mind) + (anxiety)= - Anxious status of a mind. also known as stimulates and improves the digestive fire and metabolism at a cellular level ( It can be correlated to GAD.
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