Objective: To investigate the association of Down syndrome screening results in successive pregnancies, and assess the impacts of including previous screening results in the current risk estimation on screening performance.
Methods: The study was based on 56,951 women who had triple marker screening in two or more singleton pregnancies in the Ontario Maternal Serum Screening (MSS) program between October 1993 and September 2000. The problem of recurrent false positive results was examined by comparing screening results from different pregnancies in the same individuals. Between-pregnancy associations in the levels of serum markers were estimated using correlation analysis. A published method was used to adjust current risk estimation for previous screening results. The effect of this adjustment was assessed by comparing screening performances prior and subsequent to the adjustment.
Results: The observed false positive rate (FPR) in subsequent pregnancies was 2.5 times higher than that expected (26.4% vs 10.7%) among women who screened positive in one previous pregnancy, and 3.9 times higher (47.4% vs 12.1%) among women who screened positive in two previous pregnancies. Adjusting for a previous screening result will significantly reduce the recurrent FPR without compromising detection.
Conclusion: Risk estimation for Down syndrome may be adjusted using the screening result from a previous pregnancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pd.1867 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Progression of Amyloid Accumulation in Late Adulthood Among People With Childhood-Onset Epilepsy.
Neurology
February 2025
Departments of Child Neurology and General Practice, University of Turku and Turku University Hospital, Finland.
Background And Objectives: Previous research has demonstrated increased brain amyloid plaque load in individuals with childhood-onset epilepsy in late middle age. However, the trajectory of this process is not yet known. The aim of this study was to determine whether individuals with a history of childhood-onset epilepsy show progressive brain aging in amyloid accumulation in late adulthood (Turku Adult Childhood-Onset Epilepsy study, TACOE).
View Article and Find Full Text PDFConvolutional neural network (CNN) configuration using a learning automaton model for neonatal brain image segmentation.
PLoS One
January 2025
Department of Electrical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
CNN is considered an efficient tool in brain image segmentation. However, neonatal brain images require specific methods due to their nature and structural differences from adult brain images. Hence, it is necessary to determine the optimal structure and parameters for these models to achieve the desired results.
View Article and Find Full Text PDFPooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform.
PLoS One
January 2025
SLAC National Accelerator Laboratory, Stanford University, Stanford, California, United States of America.
Protein-Protein Interactions (PPIs) are a key interface between virus and host, and these interactions are important to both viral reprogramming of the host and to host restriction of viral infection. In particular, viral-host PPI networks can be used to further our understanding of the molecular mechanisms of tissue specificity, host range, and virulence. At higher scales, viral-host PPI screening could also be used to screen for small-molecule antivirals that interfere with essential viral-host interactions, or to explore how the PPI networks between interacting viral and host genomes co-evolve.
View Article and Find Full Text PDFParents' Experiences and Views About Use of Wearable Technology for Research and Treatment Monitoring of Children with Neurodevelopmental Disorders.
J Dev Behav Pediatr
January 2025
Department of Paediatrics, The University of Melbourne, Melbourne, Australia.
Objective: Wearable technology has potential benefits for clinical measurement with children who have neurodevelopmental disorders (NDDs). However, this cohort may experience sensory processing disorder, behavioral dysregulation, and cognitive challenges. For effective and considerate implementation, the experiences and views of parents of children with NDDs on this topic need in-depth investigation.
View Article and Find Full Text PDFIdentifying Risk Factors of Children Who Suffered Physical Abuse: A Systematic Review.
J Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopaedic Surgery, Foot and Ankle Research and Innovation Laboratory (FARIL), Massachusetts General Hospital, Harvard Medical School, Boston, MA (Flaherty, Ghandour, Mirochnik, Lucaciu, Nassour, Kwon, and Ashkani-Esfahani); the Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Kwon, Harris, and Ashkani-Esfahani); and the Department of Orthopaedic Surgery, Massachusetts General Hospital, Division Foot and Ankle, Harvard Medical School, Boston, MA (Kwon and Ashkani-Esfahani).
Background: Approximately 25% of children in the United States experience child abuse or neglect, 18% of whom are physically abused. Physicians are often in a position to differentiate accidental trauma from physical child abuse. Therefore, the aim of this study was to review recent literature for risk factors associated with physical child abuse.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!