The nature and dynamics of inflammatory changes have been studied in the liver and lungs of CBA/j mice infected with T. canis oocysts (Moscow and Irkutsk strains). It has been shown that in larval toxocariasis of mice two peaks of total leukocyte concentration are observed in the peripheral blood, on days 8 and 13-15 of invasion, which reflects terms of larvae migration via liver and lungs. The course of the inflammatory process in the parenchymatous organs of experimental animals is 7 days slower than in aseptic inflammation due to 2-4-fold inhibition of leukocyte chemotaxis and 3-fold decrease in bactericidal activity. Larval migration of Irkutsk T. canis strain from the liver to the lungs and to the brain is 7-10 days slower than in the Moscow strain.
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